ULTRASOUND AND INTRA-CLOT MICROBUBBLES ENHANCED CATHETER-DIRECTED THROMBOLYSIS IN VITRO AND IN VIVO

被引：21
作者：
Gao, Shunji [1 ]
Zhu, Qiong [1 ]
Guo, MengJiao [1 ]
Gao, Yuan [1 ]
Dong, Xiaoxiao [1 ]
Chen, Zhong [1 ]
Liu, Zheng [1 ]
Xie, Feng [2 ]
机构：
[1] Third Mil Med Univ, Xinqiao Hosp, Dept Ultrasound, Chongqing 400037, Peoples R China
[2] Univ Nebraska Med Ctr, Internal Med Cardiol, Omaha, NE USA
来源：
ULTRASOUND IN MEDICINE AND BIOLOGY | 2017年 / 43卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Ultrasound; Thrombolysis; Microbubbles; Catheter-directed technique; TISSUE-PLASMINOGEN ACTIVATOR; DIAGNOSTIC ULTRASOUND; ACCELERATED THROMBOLYSIS; CAVITATIONAL MECHANISMS; ENDOVASCULAR TREATMENT; INERTIAL CAVITATION; SONOTHROMBOLYSIS; HEMORRHAGE; DEPENDENCE; CORONARY;
D O I：
10.1016/j.ultrasmedbio.2017.03.017
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
Insufficient penetration of microbubbles (MBs) into the vessel-obstructing thrombi significantly reduces the effectiveness of ultrasound thrombolysis (UT). The widely performed catheter-directed therapy (CDT) makes it possible to increase the local concentration of MBs in the clot. In an occluded vessel with a bypass, treatment of fresh human whole blood clots with CDT-based UT (intra-clot injection of MBs and urokinase, with ultrasound exposure) resulted in a significantly higher percentage of weight loss (35.32 +/- 15.42%), compared with CDTalone (19.64 +/- 4.71%), non-CDT-based UT (systemic administration of urokinase and MBs, with ultrasound exposure, 8.79 +/- 3.02%) and systemic thrombolysis (7.90 +/- 2.14). Ultrasound and intra-clot MB enhancement of CDT was further confirmed by a rabbit IVC thrombolysis study, where CDT-based UT resulted in significantly more effective thrombolysis compared with CDTalone. In summary, combining CDTwith intra-clot MB-induced acoustic cavitation can improve thrombolysis. (C) 2017 World Federation for Ultrasound in Medicine & Biology.
引用
收藏
页码：1671 / 1678
页数：8
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