The efficacy of diphtheria-growth factor fusion proteins is enhanced by co-administration of cytosine arabinoside in an immunodeficient mouse model of human acute myeloid leukemia

被引：20
作者：
Hogge, DE
Feuring-Buske, M
Gerhard, B
Frankel, AE
机构：
[1] British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada
[2] Univ British Columbia, Dept Med, Vancouver, BC, Canada
[3] Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA
来源：
LEUKEMIA RESEARCH | 2004年 / 28卷 / 11期
关键词：
diphtheria toxin fusion proteins; Ara-C; AML; NOD/SCID mice;
D O I：
10.1016/j.leukres.2004.03.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Addition of cytosine arabinoside (Ara-C) to truncated diphtheria toxin (DT388) fused to granulocyte macrophage-colony stimulating factor (GMCSF) or interleukin-3 (IL3) was studied in a NOD/SCID mouse model of human AML. Ara-C alone did not reduce the % human AML cells in mouse bone marrow (BM). DT(388)IL3 or DT(388)GMCSF alone reduced but did not eradicate engraftment for two of four and two of three samples, respectively. In contrast, Ara-C with DT(388)IL3 eliminated AML from mouse BM with one of four samples while DT(388)GMCSF with Ara-C eliminated or reduced AML cells as compared to mice receiving either agent alone with two of three samples. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1221 / 1226
页数：6
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