AIDS-related Mycobacterium kansasii infection with initial resistance to clarithromycin

被引：14

作者：

Burman, WJ

Stone, BL

Brown, BA

Wallace, RJ

Böttger, EC

机构：

[1] Univ Colorado, Hlth Sci Ctr, Denver Hlth Med Ctr, Mycobacteriol Lab, Denver, CO USA

[2] Univ Colorado, Hlth Sci Ctr, Dept Med, Div Infect Dis, Denver, CO USA

[3] Univ Texas, Ctr Hlth, Dept Microbiol, Tyler, TX 75710 USA

[4] Med Hsch Hannover, Inst Med Mikrobiol, D-30623 Hannover, Germany

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 1998年 / 31卷 / 02期

关键词：

D O I：

10.1016/S0732-8893(98)00013-3

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Clarithromycin is a promising drug for the treatment of Mycobacterium kansasii infection. We report a patient with AIDS and severe M. kansasii infection who had previously received a short course of clarithromycin for sinusitis. He had clinical failure of treatment using clarithromycin plus ethambutol, and the initial isolate was found to be highly resistant to clarithromycin. Nucleotide sequencing of the 23S rRNA gene of this isolate demonstrated a single base mutation at position 2058, the same as that found in clarithromycin-resistant Mycobacterium avium. (C) 1998 Elsevier Science Inc.

引用

页码：369 / 371

页数：3

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