Balancing Porosity and Mechanical Properties of Titanium Samples to Favor Cellular Growth against Bacteria

被引:20
作者
Civantos, Ana [1 ]
Beltran, Ana M. [2 ]
Dominguez-Trujillo, Cristina [2 ]
Garvi, Maria D. [3 ]
Lebrato, Julian [3 ]
Rodriguez-Ortiz, Jose A. [2 ]
Garcia-Moreno, Francisco [4 ]
Cauich-Rodriguez, Juan, V [5 ]
Guzman, Julio J. [2 ]
Torres, Yadir [2 ]
机构
[1] Univ Illinois, Micro & Nanotechnol Lab, Urbana, IL 61801 USA
[2] Univ Seville, Dept Ingn & Ciencia Mat & Transporte, Escuela Politecn Super, Virgen Africa 7, Seville 41011, Spain
[3] Univ Seville, Grp TAR, Escuela Politecn Super, Seville 41004, Spain
[4] Helmholtz Zentrum Berlin Mat & Energie, Inst Appl Mat, Hahn Meitner Pl 1, D-14109 Berlin, Germany
[5] Ctr Invest Cient Yucatan AC, Unidad Mat, Merida 97205, Yucatan, Mexico
关键词
bone implant; porous titanium; cellular adhesion; bacteria colonization; osseointegration; FUNCTIONALLY GRADED MATERIALS; POROUS TITANIUM; SPACE-HOLDER; FABRICATION; ADHESION; IMPLANTS; ALLOYS; DESIGN; FOAM; NACL;
D O I
10.3390/met9101039
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Two main problems limit the success of titanium implants: bacterial infection, which restricts their osseointegration capacity; and the stiffness mismatch between the implant and the host cortical bone, which promotes bone resorption and risk of fracture. Porosity incorporation may reduce this difference in stiffness but compromise biomechanical behavior. In this work, the relationship between the microstructure (content, size, and shape of pores) and the antibacterial and cellular behavior of samples fabricated by the space-holder technique (50 vol % NH4HCO3 and three ranges of particle sizes) is established. Results are discussed in terms of the best biomechanical properties and biofunctional activity balance (cell biocompatibility and antibacterial behavior). All substrates achieved suitable cell biocompatibility of premioblast and osteoblast in adhesion and proliferation processes. It is worth to highlighting that samples fabricated with the 100-200 mu m space-holder present better mechanical behavior-in terms of stiffness, microhardness, and yield strength-which make them a very suitable material to replace cortical bone tissues. Those results exposed the relationship between the surface properties and the race of bacteria and mammalian cells for the surface with the aim to promote cellular growth over bacteria.
引用
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页数:16
相关论文
共 35 条
[1]  
AENOR, 2014, 930812014 AENOR UNEE
[2]  
[Anonymous], 2017, 1173712007 ISO
[3]   Effect of Butyrate on Collagen Expression, Cell Viability, Cell Cycle Progression and Related Proteins Expression of MG-63 Osteoblastic Cells [J].
Chang, Mei-Chi ;
Tsai, Yi-Ling ;
Liou, Eric Jein-Wein ;
Tang, Chia-Mei ;
Wang, Tong-Mei ;
Liu, Hsin-Cheng ;
Liao, Ming-Wei ;
Yeung, Sin-Yuet ;
Chan, Chiu-Po ;
Jeng, Jiiang-Huei .
PLOS ONE, 2016, 11 (11)
[4]   RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation [J].
Chen, Xiao ;
Zhi, Xin ;
Wang, Jun ;
Su, Jiacan .
BONE RESEARCH, 2018, 6
[5]   Designing bioactive porous titanium interfaces to balance mechanical properties and in vitro cells behavior towards increased osseointegration [J].
Civantos, Ana ;
Dominguez, Cristina ;
Juliana Pino, Raisa ;
Setti, Giulia ;
Jose Pavon, Juan ;
Martinez-Campos, Enrique ;
Garcia Garcia, Francisco Jose ;
Rodriguez, Jose Antonio ;
Allain, Jean Paul ;
Torres, Yadir .
SURFACE & COATINGS TECHNOLOGY, 2019, 368 :162-174
[6]   Titanium Coatings and Surface Modifications: Toward Clinically Useful Bioactive Implants [J].
Civantos, Ana ;
Martinez-Campos, Enrique ;
Ramos, Viviana ;
Elvira, Carlos ;
Gallardo, Alberto ;
Abarrategi, Ander .
ACS BIOMATERIALS SCIENCE & ENGINEERING, 2017, 3 (07) :1245-1261
[7]   Osteoblast response to porous titanium and biomimetic surface: In vitro analysis [J].
do Prado, Renata Falchete ;
de Oliveira, Femanda Saraiva ;
Nascimento, Rodrigo Dias ;
Reis de Vasconcellos, Luana Marotta ;
Carvalho, Yasmin Rodarte ;
Alves Cairo, Carlos Alberto .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2015, 52 :194-203
[8]   Bacterial behavior on coated porous titanium substrates for biomedical applications [J].
Dominguez-Trujillo, Cristina ;
Beltran, Ana M. ;
Garvi, Maria D. ;
Salazar-Moya, Alba ;
Lebrato, Julian ;
Hickey, Daniel J. ;
Rodriguez-Ortiz, Jose A. ;
Kamm, Paul H. ;
Lebrato, Clara ;
Garcia-Moreno, Francisco ;
Webster, Thomas J. ;
Torres, Yadir .
SURFACE & COATINGS TECHNOLOGY, 2019, 357 :896-902
[9]   Improvement of the balance between a reduced stress shielding and bone rit ingrowth by bioactive coatings onto porous titanium substrates [J].
Dominguez-Trujillo, Cristina ;
Ternero, Fatima ;
Antonio Rodriguez-Ortiz, Jose ;
Jose Pavon, Juan ;
Montealegre-Melendez, Isabel ;
Arevalo, Cristina ;
Garcia-Moreno, Francisco ;
Torres, Yadir .
SURFACE & COATINGS TECHNOLOGY, 2018, 338 :32-37
[10]   Processing of titanium foams using magnesium spacer particles [J].
Esen, Z. ;
Bor, S. .
SCRIPTA MATERIALIA, 2007, 56 (05) :341-344