Study of confounding factors influence on lung cancer diagnostics effectiveness using gas chromatography-mass spectrometry analysis of exhaled breath

被引：9
作者：
Gashimova, Elina [1 ]
Osipova, Anna [1 ]
Temerdashev, Azamat [1 ]
Porkhanov, Vladimir [2 ]
Polyakov, Igor [2 ]
Perunov, Dmitry [2 ]
Dmitrieva, Ekaterina [1 ]
机构：
[1] Kuban State Univ, Dept Analyt Chem, Krasnodar, Russia
[2] Reg Clin Hosp 1, Res Inst, Krasnodar, Russia
来源：
BIOMARKERS IN MEDICINE | 2021年 / 15卷 / 11期
基金：
俄罗斯基础研究基金会;
关键词：
confounding factors; exhaled breath; GC-MS; lung cancer diagnostics; volatile organic compounds; VOLATILE ORGANIC-COMPOUNDS; POTENTIAL MARKERS; ELECTRONIC NOSE; DISCRIMINATION; IDENTIFICATION; PREDICTION; VOCS; AGE;
D O I：
10.2217/bmm-2020-0828
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: The purpose of this study was to estimate volatile organic compounds (VOCs) ability to distinguish exhaled breath samples of lung cancer patients and healthy volunteers and to assess the effect of smoking status and gender on parameters. Patients & methods: Exhaled breath samples of 40 lung cancer patients and 40 healthy individuals were analyzed using gas chromatography-mass spectrometry. Influence of other factors on the exhaled breath VOCs profile was investigated. Results: Some parameters correlating with the disease status were affected by other factors. Excluding these parameters allows creating a logistic regression diagnostic model with 83% sensitivity and 81% specificity. Conclusion: Influence of other factors on the exhaled breath VOCs profile has to be taken into account to avoid misleading results.
引用
收藏
页码：821 / 829
页数：9
相关论文
共 40 条
  • [1] The potential of breath analysis to improve outcome for patients with lung cancer
    Antoniou, S. X.
    Gaude, E.
    Ruparel, M.
    van der Schee, M. P.
    Janes, S. M.
    Rintoul, R. C.
    [J]. JOURNAL OF BREATH RESEARCH, 2019, 13 (03)
  • [2] Expiratory flow rate, breath hold and anatomic dead space influence electronic nose ability to detect lung cancer
    Bikov, Andras
    Hernadi, Marton
    Korosi, Beata Zita
    Kunos, Laszlo
    Zsamboki, Gabriella
    Sutto, Zoltan
    Tarnoki, Adam Domonkos
    Tarnoki, David Laszlo
    Losonczy, Gyorgy
    Horvath, Ildiko
    [J]. BMC PULMONARY MEDICINE, 2014, 14
  • [3] Factors that influence the volatile organic compound content in human breath
    Blanchet, L.
    Smolinska, A.
    Baranska, A.
    Tigchelaar, E.
    Swertz, M.
    Zhernakova, A.
    Dallinga, J. W.
    Wijmenga, C.
    van Schooten, F. J.
    [J]. JOURNAL OF BREATH RESEARCH, 2017, 11 (01)
  • [4] Exhaled breath and oral cavity VOCs as potential biomarkers in oral cancer patients
    Bouza, M.
    Gonzalez-Soto, J.
    Pereiro, R.
    de Vicente, J. C.
    Sanz-Medel, A.
    [J]. JOURNAL OF BREATH RESEARCH, 2017, 11 (01)
  • [5] Identification of volatile lung cancer markers by gas chromatography-mass spectrometry: comparison with discrimination by canines
    Buszewski, Boguslaw
    Ligor, Tomasz
    Jezierski, Tadeusz
    Wenda-Piesik, Anna
    Walczak, Marta
    Rudnicka, Joanna
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2012, 404 (01) : 141 - 146
  • [6] The lung cancer breath signature: a comparative analysis of exhaled breath and air sampled from inside the lungs
    Capuano, Rosamaria
    Santonico, Marco
    Pennazza, Giorgio
    Ghezzi, Silvia
    Martinelli, Eugenio
    Roscioni, Claudio
    Lucantoni, Gabriele
    Galluccio, Giovanni
    Paolesse, Roberto
    Di Natale, Corrado
    D'Amico, Arnaldo
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [7] Colarusso, 2020, DEMENT, V12, pE12088
  • [8] Review-Non-Invasive Monitoring of Human Health by Exhaled Breath Analysis: A Comprehensive Review
    Das, Sagnik
    Pal, Mrinal
    [J]. JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 2020, 167 (03)
  • [9] Exhaled breath testing - A tool for the clinician and researcher
    Davis, Michael D.
    Fowler, Stephen J.
    Montpetit, Alison J.
    [J]. PAEDIATRIC RESPIRATORY REVIEWS, 2019, 29 : 37 - 41
  • [10] Prediction of response to anti-PD-1 therapy in patients with non-small-cell lung cancer by electronic nose analysis of exhaled breath
    de Vries, R.
    Muller, M.
    van der Noort, V.
    Theelen, W. S. M. E.
    Schouten, R. D.
    Hummelink, K.
    Muller, S. H.
    Wolf-Lansdorf, M.
    Dagelet, J. W. F.
    Monkhorst, K.
    Zee, A. H. Maitland-van der
    Baas, P.
    Sterk, P. J.
    van den Heuvel, M. M.
    [J]. ANNALS OF ONCOLOGY, 2019, 30 (10) : 1660 - 1666
1234