Antidiabetic activities of chalcones isolated from a Japanese herb, Angelica keiskei

被引：129

作者：

Enoki, Tatsuji ^{[1
]}

Ofinogi, Hiromu ^{[1
]}

Nagamine, Kinuko ^{[1
]}

Kudo, Yoko ^{[1
]}

Sugiyama, Katsumi ^{[1
]}

Tanabe, Masashige ^{[1
]}

Kobayashi, Eiji ^{[1
]}

Sagawa, Hiroaki ^{[1
]}

Kato, Ikunoshin ^{[1
]}

机构：

[1] Takara Bio Inc, Biotechnol Res Labs, Otsu, Shiga 5202193, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2007年 / 55卷 / 15期

关键词：

diabetes; insulin-like; adipocyte differentiation; glucose-uptake; chalcone; Angelica keisket; 4-hydroxyderricin; xanthoangelol; PPAR-gamma;

D O I：

10.1021/jf070720q

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Diabetes mellitus is a chronic disease that is characterized by hyperglycemia caused by insufficient insulin action. We have explored the edible ingredients from folk medicines in Japan that contain substances complementing insulin action, such as the induction of adipocyte differentiation and the enhancement of glucose uptake. We eventually found that the ethanol extract from a Japanese herb "Ashitaba", Angelica keiskei, contained two major chalcones of 4-hydroxyderricin (4-HD) and xanthoangelol that showed strong insulin-like activities via a pathway independent of the peroxisome proliferator-activated receptor-gamma activation. The 4-HD especially showed the preventive effects on the progression of diabetes in genetically diabetic KK-A(y) mice.

引用

页码：6013 / 6017

页数：5

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