More than merely drug resistance

被引：2

作者：

Chen, Yu-Xiang ^{[1
]}

Javid, Babak ^{[1
]}

机构：

[1] Tsinghua Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Ctr Global Hlth & Infect Dis, Sch Med, Beijing, Peoples R China

来源：

NATURE MICROBIOLOGY | 2018年 / 3卷 / 10期

关键词：

MYCOBACTERIUM-TUBERCULOSIS;

D O I：

10.1038/s41564-018-0250-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The H445Y mutation in the beta-subunit of RNA polymerase in Mycobacterium tuberculosis causes resistance to the antibiotic rifampicin and changes mycobacterial lipid composition. Infection with rpoB H445Y results in metabolic shifts that allow the bacteria to bypass a key host inflammatory response.

引用

页码：1078 / 1079

页数：2

共 11 条

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