Agonistic anti-CD40 therapy synergizes with LAG-3-blocking antibodies

被引：1

作者：

Mueller, Philipp ^{[1
]}

Thommen, Daniela S. ^{[1
,2
]}

Zippelius, Alfred ^{[1
,2
]}

机构：

[1] Univ Hosp Basel, Lab Canc Immunol, Dept Biomed, Basel, Switzerland

[2] Univ Hosp Basel, Dept Med Oncol, Petersgraben 4, CH-4031 Basel, Switzerland

来源：

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | 2017年 / 55卷 / 08期

关键词：

CD40L; LAG-3; immune checkpoint blockade; immuno therapy combinations; MULTIPLE INHIBITORY RECEPTORS; T-CELLS; CD40; ANTIBODIES; CANCER; LAG-3; PD-1;

D O I：

10.5414/CPXCES15EA06

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：692 / 694

页数：3

共 9 条

[1] CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans [J].

Beatty, Gregory L. ;

Chiorean, Elena G. ;

Fishman, Matthew P. ;

Saboury, Babak ;

Teitelbaum, Ursina R. ;

Sun, Weijing ;

Huhn, Richard D. ;

Song, Wenru ;

Li, Dongguang ;

Sharp, Leslie L. ;

Torigian, Drew A. ;

O'Dwyer, Peter J. ;

Vonderheide, Robert H. .

SCIENCE, 2011, 331 (6024) :1612-1616

[2] Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection [J].

Blackburn, Shawn D. ;

Shin, Haina ;

Haining, W. Nicholas ;

Zou, Tao ;

Workman, Creg J. ;

Polley, Antonio ;

Betts, Michael R. ;

Freeman, Gordon J. ;

Vignali, Dario A. A. ;

Wherry, E. John .

NATURE IMMUNOLOGY, 2009, 10 (01) :29-37

[3] Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells [J].

Grosso, Joseph F. ;

Goldberg, Monica V. ;

Getnet, Derese ;

Bruno, Tullia C. ;

Yen, Hung-Rong ;

Pyle, Kristin J. ;

Hipkiss, Edward ;

Vignali, Dario A. A. ;

Pardoll, Drew M. ;

Drake, Charles G. .

JOURNAL OF IMMUNOLOGY, 2009, 182 (11) :6659-6669

[4] Inhibitory Fcγ Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies [J].

Li, Fubin ;

Ravetch, Jeffrey V. .

SCIENCE, 2011, 333 (6045) :1030-1034

[5] Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer [J].

Matsuzaki, Junko ;

Gnjatic, Sacha ;

Mhawech-Fauceglia, Paulette ;

Beck, Amy ;

Miller, Austin ;

Tsuji, Takemasa ;

Eppolito, Cheryl ;

Qian, Feng ;

Lele, Shashikant ;

Shrikant, Protul ;

Old, Lloyd J. ;

Odunsi, Kunle .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (17) :7875-7880

[6] The CD4-like molecule LAG-3, biology and therapeutic applications [J].

Sierro, Sophie ;

Romero, Pedro ;

Speiser, Daniel E. .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2011, 15 (01) :91-101

[7] Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors [J].

Thommen, Daniela S. ;

Schreiner, Jens ;

Mueller, Philipp ;

Herzig, Petra ;

Roller, Andreas ;

Belousov, Anton ;

Umana, Pablo ;

Pisa, Pavel ;

Klein, Christian ;

Bacac, Marina ;

Fischer, Ozana S. ;

Moersig, Wolfgang ;

Prince, Spasenija Savic ;

Levitsky, Victor ;

Karanikas, Vaios ;

Lardinois, Didier ;

Zippelius, Alfred .

CANCER IMMUNOLOGY RESEARCH, 2015, 3 (12) :1344-1355

[8] Agonistic CD40 Antibodies and Cancer Therapy [J].

Vonderheide, Robert H. ;

Glennie, Martin J. .

CLINICAL CANCER RESEARCH, 2013, 19 (05) :1035-1043

[9] Induced PD-L1 Expression Mediates Acquired Resistance to Agonistic Anti-CD40 Treatment [J].

Zippelius, Alfred ;

Schreiner, Jens ;

Herzig, Petra ;

Mueller, Philipp .

CANCER IMMUNOLOGY RESEARCH, 2015, 3 (03) :236-244

← 1 →