Deciphering the roles of FOXO1 in human neoplasms

被引：57

作者：

Jiang, Shuai ^{[1
,2
]}

Li, Tian ^{[3
]}

Yang, Zhi ^{[3
]}

Hu, Wei ^{[3
]}

Yang, Yang ^{[1
,3
]}

机构：

[1] Northwest Univ, Fac Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Dept Aerosp Med, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China

[3] Fourth Mil Med Univ, Dept Biomed Engn, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CANCER | 2018年 / 143卷 / 07期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Forkhead box O1; neoplasm; phosphorylation; micro-RNA; apoptosis; proliferation; ENDOPLASMIC-RETICULUM STRESS; ISCHEMIA-REPERFUSION INJURY; TRANSCRIPTION FACTOR FOXO1; F-BOX PROTEINS; BREAST-CANCER; DOWN-REGULATION; GENOMIC INSTABILITY; MYELOID-LEUKEMIA; TUMOR-SUPPRESSOR; OXIDATIVE STRESS;

D O I：

10.1002/ijc.31338

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of FOXO1 in neoplasms. This article may serve as a guide for future research and identify FOXO1 as a potent therapeutic target in neoplasms.

引用

页码：1560 / 1568

页数：9

共 120 条

[1]

Abdelnour-Berchtold E, 2010, ANTICANCER RES, V30, P799

[2]

[Anonymous], BR J PHARM

[3] Fat and the fate of pancreatic tumours [J].