Graphene-Oxide-Modified Lanthanide Nanoprobes for Tumor-Targeted Visible/NIR-II Luminescence Imaging

被引:102
作者
Song, Xiaorong [1 ,2 ,3 ]
Li, Shihua [3 ]
Guo, Hanhan [1 ,2 ]
You, Wenwu [1 ,2 ]
Shang, Xiaoying [1 ,2 ]
Li, Renfu [1 ,2 ]
Tu, Datao [1 ,2 ]
Zheng, Wei [1 ,2 ]
Chen, Zhuo [1 ,2 ]
Yang, Huanghao [3 ]
Chen, Xueyuan [1 ,2 ]
机构
[1] Chinese Acad Sci, Fujian Inst Res Struct Matter, CAS Key Lab Design & Assembly Funct Nanostruct, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China
[2] Chinese Acad Sci, Fujian Inst Res Struct Matter, Fujian Key Lab Nanomat, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China
[3] Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350116, Fujian, Peoples R China
基金
中国博士后科学基金;
关键词
graphene oxide; lanthanides; luminescent nanoprobes; NIR-II bioimaging; tumor targeting; UP-CONVERSION NANOPARTICLES; UPCONVERTING NANOPARTICLES; ELECTRONIC-STRUCTURES; NANOCRYSTALS; PHASE; IMPACT; CANCER; BRIGHT; CELLS; LIGHT;
D O I
10.1002/anie.201909416
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The synthesis of hydrophilic lanthanide-doped nanocrystals (Ln(3+)-NCs) with molecular recognition ability for bioimaging currently remains a challenge. Herein, we present an effective strategy to circumvent this bottleneck by encapsulating Ln(3+)-NCs in graphene oxide (NCs@GO). Monodisperse NCs@GO was prepared by optimizing GO size and core-shell structure of NaYF4:Yb,Er@NaYF4, thus combining the intense visible/near-infrared II (NIR-II) luminescence of NCs and the unique surface properties and biomedical functions of GO. Such nanostructures not only feature broad solvent dispersibility, efficient cell uptake, and excellent biocompatibility but also enable further modifications with various agents such as DNA, proteins, or nanoparticles without tedious procedures. Moreover, we demonstrate in proof-of-concept experiments that NCs@GO can realize simultaneous intracellular tracking and microRNA-21 visualization, as well as highly sensitive in vivo tumor-targeted NIR-II imaging at 1525 nm.
引用
收藏
页码:18981 / 18986
页数:6
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