Effects of Laboratory Housing Conditions on Core Temperature and Locomotor Activity in Mice

被引:5
|
作者
Russell, Lauren N. [1 ]
Hyatt, William S. [1 ]
Gannon, Brenda M. [1 ]
Simecka, Christy M. [2 ]
Randolph, Mildred M. [2 ]
Fantegrossi, William E. [1 ]
机构
[1] Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, Little Rock, AR 72205 USA
[2] Univ Arkansas Med Sci, Div Lab Anim Med, Little Rock, AR 72205 USA
来源
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE | 2021年 / 60卷 / 03期
基金
美国国家卫生研究院;
关键词
BODY-TEMPERATURE; AMBIENT-TEMPERATURE; MOUSE; METABOLISM; PHYSIOLOGY; RESPONSES; ANXIETY; DENSITY; STRESS; SLEEP;
D O I
10.30802/AALAS-JAALAS-20-000093
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Drug developers worldwide assess compound safety and efficacy using measures that include mouse core temperature and locomotor activity. Subtle differences in animal housing conditions between institutions can alter these values, impacting scientific rigor and reproducibility. In these studies, adult male NIH Swiss mice were surgically implanted with radiotelemetry probes that simultaneously monitored core temperature and locomotor activity across various housing conditions. In the first study, ambient temperature was varied between 20 degrees C and 28 degrees C in groups of singly housed mice. Additional studies held the mice at a constant ambient temperature and examined the effects of cage density (housing animals singly or in groups of 3 or 6), bedding change and provision of nesting material, and the availability of a running wheel on core temperature and locomotor activity. Mice overwhelmingly maintained species-typical core temperatures across all ambient temperatures, across all housing conditions, when bedding was fresh or old, and with or without the provision of cotton squares as nesting material. However, engaging in wheel running and the combination of fresh bedding and cotton squares transiently increased core temperatures beyond the species-typical range. Similarly, the circadian distribution of locomotor activity was significantly disrupted by placing animals in cages with fresh bedding or nesting material, or by performing both of these manipulations concurrently during the light period. These findings suggest that standard husbandry practices and common housing conditions may transiently affect core temperature in adult mice. Furthermore, these practices may have profound and relatively long-lasting effects on motor activity and the regulation of circadian rhythms.
引用
收藏
页码:272 / 280
页数:9
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