The Effect of Transplantation of Olfactory Ensheathing Cells on the Size of Posttraumatic Spinal Cord Cysts

被引：5
|
作者：
Voronova, A. D. [1 ]
Stepanova, O. V. [1 ,5 ]
Chadin, A. V. [1 ]
Fursa, G. A. [1 ,3 ]
Karsuntseva, E. K. [1 ,3 ]
Valikhov, M. P. [1 ,5 ]
Semkina, A. S. [1 ,2 ]
Reshetov, I. V. [4 ]
Chekhonin, V. P. [1 ,2 ]
机构：
[1] Minist Hlth Russian Federat, VP Serbsky Natl Med Res Ctr Psychiat & Narcol, Moscow, Russia
[2] NI Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, Russia
[3] Moscow MV Lomonosov State Univ, Moscow, Russia
[4] IM Sechenov First Moscow State Med Univ, Univ Clin Hosp 1, Minist Hlth Russian Federat, Moscow, Russia
[5] Minist Hlth Russian Federat, Natl Med Res Ctr Cardiol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2021年 / 171卷 / 01期
关键词：
human olfactory mucosa; olfactory ensheathing cells; cell therapy; posttraumatic cysts of the spinal cord; NEURAL PRECURSOR CELLS; STEM-CELLS; RATS; RECOVERY; REGENERATION; INJURY;
D O I：
10.1007/s10517-021-05183-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of transplantation of ensheathing cells obtained from the olfactory mucosa of rats and humans on the size of posttraumatic spinal cord cysts. MRI examination showed that transplantation of these cells into experimental posttraumatic cysts of the spinal cord led to a significant decrease in cyst volume and even their complete disappearance in two animals receiving transplantation of rat or human cells. These findings attested to regenerative processes developing as a result of ensheathing cell transplantation. Further studies in this field will be aimed at elucidation of the mechanisms underlying spinal cord regeneration in the area of posttraumatic cysts after transplantation of ensheathing cells.
引用
收藏
页码：122 / 126
页数：5
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