The combination of Young's syndrome and small cell lung cancer-A spiky connection?

被引：0

作者：

Forster, Martin ^{[1
]}

Enting, Deborah ^{[2
]}

Nicholson, Andrew G. ^{[3
,4
]}

O'Brien, Mary ^{[1
]}

Popat, Sanjay ^{[1
,3
]}

机构：

[1] Royal Marsden Hosp, Lung Unit, London SW3 6JJ, England

[2] Guys Hosp, London SE1 9RT, England

[3] Imperial Coll London, Natl Heart & Lung Inst, London, England

[4] Royal Brompton Hosp, Dept Histopathol, London SW3 6NP, England

来源：

LUNG CANCER | 2010年 / 67卷 / 03期

关键词：

Small cell lung cancer; SCLC; Young's syndrome; Non smoker; Hedgehog signalling; END RESULTS DATABASE; OBSTRUCTIVE AZOOSPERMIA; NONSMOKING WOMEN; PRIMARY CILIUM; UNITED-STATES; DISEASE; RISK; OVEREXPRESSION; EPIDEMIOLOGY; SURVEILLANCE;

D O I：

10.1016/j.lungcan.2009.10.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma typically associated with smoking The incidence of the disease has reduced in recent years in Western Europe as smoking habits have changed [1]. SCLC in never smokers is rare and aetiology unclear Young's syndrome is another rare condition, characterized by chronic sinopulmonary infection and obstructive azoospennia The pathobiology of this is also poorly understood Here we describe a case of both Young syndrome and SCLC in a never smoker, and raise the possibility of a common aetiology underpinned by aberrant hedgehog signalling (C) 2009 Elsevier Ireland Ltd All rights reserved

引用

页码：372 / 375

页数：4

共 34 条

[1] PREEXISTING LUNG-DISEASE AND LUNG-CANCER AMONG NONSMOKING WOMEN
ALAVANJA, MCR
BROWNSON, RC
BOICE, JD
HOCK, E
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1992, 136 (06) : 623 - 632
[2] Nuclear overexpression of the E2F3 transcription factor in human lung cancer
Cooper, Colin S.
Nicholson, Andrew G.
Foster, Christopher
Dodson, Andrew
Edwards, Sandra
Fletcher, Anne
Roe, Toby
Clark, Jeremy
Joshi, Anupam
Norman, Andrew
Feber, Andrew
Lin, Dongmei
Gao, Yanning
Shipley, Janet
Cheng, Shu-Jun
[J]. LUNG CANCER, 2006, 54 (02) : 155 - 162
[3] Vertebrate Smoothened functions at the primary cilium
Corbit, KC
Aanstad, P
Singla, V
Norman, AR
Stainier, DYR
Reiter, JF
[J]. NATURE, 2005, 437 (7061) : 1018 - 1021
[4] DELONGH R, 1992, THORAX, V47, P184
[5] Autosomal dominant polycystic kidney disease is associated with an increased prevalence of radiographic bronchiectasis
Driscoll, James A.
Bhalla, Sanjeev
Liapis, Helen
Ibricevic, Aida
Brody, Steven L.
[J]. CHEST, 2008, 133 (05) : 1181 - 1188
[6] Cilia and disease
Eley, L
Yates, LM
Goodship, JA
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2005, 15 (03) : 308 - 314
[7] Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas
Gialmanidis, Ioannis P.
Bravou, Vasiliki
Amanetopoulou, Stavroula G.
Varakis, John
Kourea, Helen
Papadaki, Helen
[J]. LUNG CANCER, 2009, 66 (01) : 64 - 74
[8] Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database
Govindan, Ramaswamy
Page, Nathan
Morgensztern, Daniel
Read, William
Tierney, Ryan
Vlahiotis, Anna
Spitznagel, Edward L.
Piccirillo, Jay
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (28) : 4539 - 4544
[9] YOUNGS SYNDROME - OBSTRUCTIVE AZOOSPERMIA AND CHRONIC SINOPULMONARY INFECTIONS
HANDELSMAN, DJ
CONWAY, AJ
BOYLAN, LM
TURTLE, JR
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (01) : 3 - 9
[10] Hann CL, 2008, ONCOLOGY-NY, V22, P1486

← 1 2 3 4 →