High-performance liquid chromatographic enantioseparation of aminonaphthol analogs on polysaccharide-based chiral stationary phases

被引：12

作者：

Ilisz, Istvan ^{[1
]}

Pataj, Zoltan ^{[1
]}

Berkecz, Robert ^{[1
]}

Szatmari, Istvan ^{[2
]}

Fulop, Ferenc ^{[2
]}

Peter, Antal ^{[1
]}

机构：

[1] Univ Szeged, Dept Inorgan & Analyt Chem, H-6720 Szeged, Hungary

[2] Univ Szeged, Inst Pharmaceut Chem, H-6720 Szeged, Hungary

来源：

JOURNAL OF CHROMATOGRAPHY A | 2010年 / 1217卷 / 17期

关键词：

Column liquid chromatography; Enantiomer separation; Aminonaphthol analogs; AmyCoat (TM) column; CelluCoat (TM) column; 2-(ALPHA-AMINOBENZYL)-1-NAPHTHOL ANALOGS; STEREOSELECTIVE SYNTHESIS; 1-(ALPHA-AMINOBENZYL)-2-NAPHTHOL; DIETHYLZINC;

D O I：

10.1016/j.chroma.2010.02.031

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

High-performance liquid chromatographic methods were developed for the separation of the enantiomers of five new aminonaphthol analogs possessing two chiral centers. The direct separations were performed on chiral stationary phases containing either amylose-tris-3,5-dimethylphenyl carbamate (Kromasil (R) AmyCoat (TM) column) or cellulose-tris-3,5-dimethylphenyl carbamate (Kromasil (R) CelluCoat (TM) column) as chiral selector. The experimental data are utilized to discuss the effects of the mobile phase composition, the nature of the alcoholic modifier and the specific structural features of the analytes on the retention and separation. The elution sequence was determined in all cases; no general regularities could be established. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：2980 / 2985

页数：6

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