Transcranial Magnetic Stimulation-EEG Biomarkers of Poststroke Upper-Limb Motor Function

被引:16
作者
Hordacre, Brenton [1 ]
Ghosh, Rukmini [2 ]
Goldsworthy, Mitchell R. [2 ,3 ]
Ridding, Michael C. [1 ]
机构
[1] Univ South Australia, Div Hlth Sci, Implementat & Clin Translat Hlth IIMPACT, Adelaide, SA, Australia
[2] Univ Adelaide, Adelaide Med Sch, Robinson Res Inst, Adelaide, SA, Australia
[3] Univ Adelaide, Adelaide Med Sch, Discipline Psychiat, Adelaide, SA, Australia
基金
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词
Motor Cortex; transcranial magnetic stimulation; electroencephalography; TMS-evoked potential; stroke; biomarker; INTRACORTICAL INHIBITION; BRAIN RESPONSES; FORCE CONTROL; STROKE; RECOVERY; TMS; CORTEX; EXCITABILITY; PLASTICITY; CONNECTIVITY;
D O I
10.1016/j.jstrokecerebrovasdis.2019.104452
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Motor evoked potentials obtained with transcranial magnetic stimulation (TMS) can provide valuable information to inform stroke neurophysiology and recovery but are difficult to obtain in all stroke survivors due to high stimulation thresholds. Objective: To determine whether transcranial magnetic stimulation evoked potentials (TEPs) evoked using a lower stimulus intensity, below that necessary for recording motor evoked potentials, could serve as a marker of poststroke upper-limb motor function and were different compared to healthy adults. Methods: Eight chronic stroke survivors (66 +/- 21 years) and 15 healthy adults (53 +/- 10 years) performed a motor function task using a customized grip-lift manipulandum. TMS was applied to the lesioned motor cortex, with TEPs recorded using simultaneous high-definition electroencephalography (EEG). Results: Stroke participants demonstrated greater hold ratio with the manipulandum. Cluster-based statistics revealed larger P30 amplitude in stroke participants, with significant clusters over frontal (P = .016) and parietal-occipital electrodes (P = .023). There was a negative correlation between the N45 peak amplitude and hold ratio in stroke participants (r = -.83, P = .02), but not controls. Conclusions: TEPs can be recorded using lower stimulus intensities in chronic stroke. The global P30 TEP response differed between stroke participants and healthy controls, with results suggesting that the TEP can be used as a biomarker of upper-limb behavior.
引用
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页数:10
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共 54 条
[1]   Understanding long-term unmet needs in Australian survivors of stroke [J].
Andrew, Nadine E. ;
Kilkenny, Monique ;
Naylor, Rebecca ;
Purvis, Tara ;
Lalor, Erin ;
Moloczij, Natasha ;
Cadilhac, Dominique A. .
INTERNATIONAL JOURNAL OF STROKE, 2014, 9 :106-112
[2]   Biomarkers of stroke recovery: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable [J].
Boyd, Lara A. ;
Hayward, Kathryn S. ;
Ward, Nick S. ;
Stinear, Cathy M. ;
Rosso, Charlotte ;
Fisher, Rebecca J. ;
Carter, Alexandre R. ;
Leff, Alex P. ;
Copland, David A. ;
Carey, Leeanne M. ;
Cohen, Leonardo G. ;
Basso, D. Michele ;
Maguire, Jane M. ;
Cramer, Steven C. .
INTERNATIONAL JOURNAL OF STROKE, 2017, 12 (05) :480-493
[3]   Proportional Recovery After Stroke Depends on Corticomotor Integrity [J].
Byblow, Winston D. ;
Stinear, Cathy M. ;
Barber, P. Alan ;
Petoe, Matthew A. ;
Ackerley, Suzanne J. .
ANNALS OF NEUROLOGY, 2015, 78 (06) :848-859
[4]   Characterization of Glutamatergic and GABAA-Mediated Neurotransmission in Motor and Dorsolateral Prefrontal Cortex Using Paired-Pulse TMS-EEG [J].
Cash, Robin F. H. ;
Noda, Yoshihiro ;
Zomorrodi, Reza ;
Radhu, Natasha ;
Farzan, Faranak ;
Rajji, Tarek K. ;
Fitzgerald, Paul B. ;
Chen, Robert ;
Daskalakis, Zafiris J. ;
Blumberger, Daniel M. .
NEUROPSYCHOPHARMACOLOGY, 2017, 42 (02) :502-511
[5]   The clinical diagnostic utility of transcranial magnetic stimulation: Report of an IFCN committee [J].
Chen, Robert ;
Cros, Didier ;
Curra, Antonio ;
Di Lazzaro, Vincenzo ;
Lefaucheur, Jean-Pascal ;
Magistris, Michel R. ;
Mills, Kerry ;
Roesler, Kai M. ;
Triggs, William J. ;
Ugawa, Yoshikazu ;
Ziemann, Ulf .
CLINICAL NEUROPHYSIOLOGY, 2008, 119 (03) :504-532
[6]   Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke [J].
Clarkson, Andrew N. ;
Huang, Ben S. ;
MacIsaac, Sarah E. ;
Mody, Istvan ;
Carmichael, S. Thomas .
NATURE, 2010, 468 (7321) :305-U193
[7]   Somatotopy and movement representation sites following cortical stroke [J].
Cramer, SC ;
Crafton, KR .
EXPERIMENTAL BRAIN RESEARCH, 2006, 168 (1-2) :25-32
[8]   Repairing the human brain after stroke. II. Restorative therapies [J].
Cramer, Steven C. .
ANNALS OF NEUROLOGY, 2008, 63 (05) :549-560
[9]   Pharmacophysiology of TMS-evoked EEG potentials: A mini-review [J].
Darmani, Ghazaleh ;
Ziemann, Ulf .
BRAIN STIMULATION, 2019, 12 (03) :829-831
[10]   EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis [J].
Delorme, A ;
Makeig, S .
JOURNAL OF NEUROSCIENCE METHODS, 2004, 134 (01) :9-21