Improving the role of immune checkpoint inhibitors in the management of advanced urothelial carcinoma, where do we stand?

被引：2
作者：
Houssiau, Helene [1 ]
Seront, Emmanuel [1 ]
机构：
[1] Ctr Hosp Jolimont, Dept Med Oncol, Rue Ferrer 159, B-7100 Haine Saint Paul, Belgium
来源：
TRANSLATIONAL ONCOLOGY | 2022年 / 19卷
关键词：
Urothelial carcinoma; Immune checkpoint inhibitors; Maintenance strategy; PD-L1; Platinum-based strategy; CISPLATIN-INELIGIBLE PATIENTS; INVASIVE BLADDER-CANCER; PHASE-II TRIAL; SINGLE-ARM; SUPPORTIVE CARE; OPEN-LABEL; CHEMOTHERAPY; MULTICENTER; ATEZOLIZUMAB; PLUS;
D O I：
10.1016/j.tranon.2022.101387
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immune checkpoint inhibitors (ICIs) have significantly improved the outcome of patients with metastatic umthelial cancer (mUC). If these agents were first used in monotherapy after failure of platinum-based chemotherapy, new strategies have been evaluated in the last years, including association of ICIs, ICI plus chemotherapy association or maintenance therapy. This maintenance concept allows a better management of mUC, which is particularly interesting in cisplatin-ineligible patients. This paper aims to review the current knowledge of ICIs in urothelial carcinoma as well as the new indications of these agents in mUC.
引用
收藏
页数：11
相关论文
共 50 条
  • [41] The evolving role of checkpoint inhibitors in the treatment of urothelial carcinoma
    Tang, Guyu
    Liu, Jing
    Qi, Lin
    Li, Yuan
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2023, 89 (01) : 93 - 113
  • [42] Progress of immune checkpoint inhibitors in the treatment of advanced hepatocellular carcinoma
    Liu, Tong
    Meng, Guorui
    Ma, Shihui
    You, Junqi
    Yu, Liang
    He, Risheng
    Zhao, Xudong
    Cui, Yunfu
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [43] Immunotherapy with checkpoint inhibitors in local advanced and metastatic urothelial carcinoma
    Miller, Kurt
    Gschwend, Juergen E.
    Merseburger, Axel
    Retz, Margitta
    Stenzl, Arnulf
    AKTUELLE UROLOGIE, 2018, 49 (02) : 142 - 156
  • [44] Impact of Performance Status on Oncologic Outcomes in Patients with Advanced Urothelial Carcinoma Treated with Immune Checkpoint Inhibitor: A Systematic Review and Meta-analysis
    Kawada, Tatsushi
    Yanagisawa, Takafumi
    Mostafaei, Hadi
    Motlagh, Reza Sari
    Quhal, Fahad
    Rajwa, Pawel
    Laukhtina, Ekaterina
    von Deimling, Markus
    Bianchi, Alberto
    Majdoub, Mohammed
    Pallauf, Maximilian
    Pradere, Benjamin
    Teoh, Jeremy Yuen-Chun
    Karakiewicz, Pierre I.
    Araki, Motoo
    Shariat, Shahrokh F.
    EUROPEAN UROLOGY FOCUS, 2023, 9 (02): : 264 - 274
  • [45] Treatment options for advanced urothelial cancer after progression on chemotherapy and immune checkpoint inhibitors: a literature review
    Koshkin, Vadim S.
    Osbourne, Appledene S.
    Grivas, Petros
    TRANSLATIONAL ANDROLOGY AND UROLOGY, 2021, 10 (10) : 4022 - 4035
  • [46] Combination Strategies on the Basis of Immune Checkpoint Inhibitors in Non-Small-Cell Lung Cancer: Where Do We Stand?
    Qiao, Meng
    Jiang, Tao
    Ren, Shengxiang
    Zhou, Caicun
    CLINICAL LUNG CANCER, 2018, 19 (01) : 1 - 11
  • [47] Prognostic and Predictive Factors in Advanced Urothelial Carcinoma Treated with Immune Checkpoint Inhibitors: A Review of the Current Evidence
    Rebuzzi, Sara Elena
    Banna, Giuseppe Luigi
    Murianni, Veronica
    Damassi, Alessandra
    Giunta, Emilio Francesco
    Fraggetta, Filippo
    De Giorgi, Ugo
    Cathomas, Richard
    Rescigno, Pasquale
    Brunelli, Matteo
    Fornarini, Giuseppe
    CANCERS, 2021, 13 (21)
  • [48] Advancements in the research of immune checkpoint inhibitors for the treatment of advanced esophageal squamous cell carcinoma
    Sun, Mengfei
    Yang, Pengjie
    Wang, Weisong
    Yu, Yongjun
    Yang, Dongdong
    Ping, Yaodong
    Zhu, Benben
    AMERICAN JOURNAL OF CANCER RESEARCH, 2024, 14 (05): : 1981 - 1998
  • [49] Adjuvant immune checkpoint inhibitors for urothelial carcinoma: systematic review and Meta-analysis
    Sayyid, Rashid K.
    Bernardino, Rui
    Chavarriaga, Julian
    Kumar, Ravi
    Randhawa, Harkanwal
    Wettstein, Marian S.
    Cockburn, Jessica Grace
    Klaassen, Zachary
    Fleshner, Neil E.
    WORLD JOURNAL OF UROLOGY, 2024, 42 (01)
  • [50] Advances in Immune Checkpoint Inhibitors for Advanced Hepatocellular Carcinoma
    Chen, Yue
    Hu, Haoyue
    Yuan, Xianglei
    Fan, Xue
    Zhang, Chengda
    FRONTIERS IN IMMUNOLOGY, 2022, 13
12345