Immunoselection techniques in hematopoietic stem cell transplantation

被引：5
作者：
Pira, Giuseppina Li [1 ]
Biagini, Simone [1 ]
Cicchetti, Elisabetta [1 ]
Merli, Pietro [1 ]
Brescia, Letizia Pomponia [1 ]
Milano, Giuseppe Maria [1 ]
Montanari, Mauro [1 ]
机构：
[1] IRCCS Bambino Gesu Childrens Hosp, Dept Pediat Hematol & Oncol, Unit Immunohematol & Transfus Med, Piazza St Onofrio 4, I-00165 Rome, Italy
来源：
TRANSFUSION AND APHERESIS SCIENCE | 2016年 / 54卷 / 03期
关键词：
Hematopoietic stem cell; Graft-versus-host disease; Alloreactive cells; Opportunistic infections; Cell manipulation; BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; HIGH-DOSE THERAPY; TERM-FOLLOW-UP; ACUTE MYELOID-LEUKEMIA; NAIVE T-CELLS; FOLLICULAR LYMPHOMA; MULTIPLE-MYELOMA;
D O I：
10.1016/j.transci.2016.05.012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hematopoietic Stem Cells Transplantation (HSCT) is an effective treatment for hematological and non-hematological diseases. The main challenge in autologous HSCT is purging of malignant cells to prevent relapse. In allogeneic HSCT graft-versus-host disease (GvHD) and opportunistic infections are frequent complications. Two types of graft manipulation have been introduced: the first one in the autologous context aimed at separating malignant cells from hematopoietic stem cells (HSC), and the second one in allogeneic HSCT aimed at reducing the incidence of GvHD and at accelerating immune reconstitution. Here we describe the manipulations used for cell purging in autologous HSCT or for T Cell Depletion (TCD) and T cell selection in allogeneic HSCT. More complex manipulations, requiring a Good Manufacturing Practice (GMP) facility, are briefly mentioned. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：356 / 363
页数：8
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