One-pot synthesis of novel pyrido[2,3-d]pyrimidines using HAp-encapsulated-γ-Fe2O3 supported sulfonic acid nanocatalyst under solvent-free conditions

被引：62
作者：
Mohsenimehr, Moona [1 ]
Mamaghani, Manouchehr [1 ]
Shirini, Farhad [1 ]
Sheykhan, Mehdi [1 ]
Moghaddam, Fatemeh Azimian [2 ]
机构：
[1] Univ Guilan, Fac Sci, Dept Chem, Rasht, Iran
[2] Islamic Azad Univ, Rasht Branch, Dept Chem, Tehran, Iran
来源：
CHINESE CHEMICAL LETTERS | 2014年 / 25卷 / 10期
关键词：
Pyrido[2,3-d]pyrimidines; Three-component; One-pot; gamma-Fe2O3@HAp-SO3H; Nanocatalyst; MAGNETICALLY SEPARABLE CATALYST; 3-COMPONENT SYNTHESIS; ANTIINFLAMMATORY AGENTS; PYRIMIDINE-DERIVATIVES; EFFICIENT; GREEN; WATER; NANOPARTICLES;
D O I：
10.1016/j.cclet.2014.04.025
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel pyrido[2,3-d]pyrimidine derivatives were synthesized through a one-pot three-component approach using HAp-encapsulated-gamma-Fe2O3 [gamma-Fe2O3@HAp-SO3H] catalyzed condensation of 6-amino-2-(methylthio or ethylthio)pyrimidin-4(3H)-one, Meldrum's acid and aryl aldehydes at 60 degrees C and under solvent-free conditions. In this protocol the use of nanocatalyst provided a green, useful and rapid method to generate the products in short reaction times and excellent yields (88%-94%). (C) 2014 Manouchehr Mamaghani. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：1387 / 1391
页数：5
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