Novel Indole Derivatives as Potential Imaging Agents for Alzheimer's Disease

被引：2
作者：
Yu, Lihai [1 ,2 ]
Scheunemann, Matthias [1 ]
Deuther-Conrad, Winnie [1 ]
Hiller, Achim [1 ]
Fischer, Steffen [1 ]
Sorger, Dietlind [3 ]
Sabri, Osama [3 ]
Jia, Hongmei [2 ]
Steinbach, Joerg [1 ]
Brust, Peter [1 ]
Liu, Boli [2 ]
机构：
[1] Inst Interdisciplinary Isotope Res, D-04318 Leipzig, Germany
[2] Beijing Normal Univ, Key Lab Radiopharmaceut, Minist Educ, Coll Chem, Beijing 100875, Peoples R China
[3] Univ Leipzig, Dept Nucl Med, D-04103 Leipzig, Germany
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2010年 / 31卷 / 01期
关键词：
beta-Amyloid; Indole; Positron emission tomography; Senile plaques; BETA-AMYLOID PLAQUES; BRAIN; PET; TAU; LOCALIZATION; BINDING;
D O I：
10.5012/bkcs.2010.31.01.177
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：177 / 180
页数：4
相关论文
共 20 条
  • [1] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES
    BRAAK, H
    BRAAK, E
    [J]. ACTA NEUROPATHOLOGICA, 1991, 82 (04) : 239 - 259
  • [2] Chikvaidze I.S., 1994, PHARM CHEM J, V28, P751
  • [3] ALZHEIMERS-DISEASE - THE AMYLOID CASCADE HYPOTHESIS
    HARDY, JA
    HIGGINS, GA
    [J]. SCIENCE, 1992, 256 (5054) : 184 - 185
  • [4] Practical methodologies for the synthesis of indoles
    Humphrey, Guy R.
    Kuethe, Jeffrey T.
    [J]. CHEMICAL REVIEWS, 2006, 106 (07) : 2875 - 2911
  • [5] IDENTIFICATION AND LOCALIZATION OF A TAU-PEPTIDE TO PAIRED HELICAL FILAMENTS OF ALZHEIMER-DISEASE
    IQBAL, K
    GRUNDKEIQBAL, I
    SMITH, AJ
    GEORGE, L
    TUNG, YC
    ZAIDI, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) : 5646 - 5650
  • [6] Klunk WE, 2003, J NEUROSCI, V23, P2086
  • [7] Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    Klunk, WE
    Engler, H
    Nordberg, A
    Wang, YM
    Blomqvist, G
    Holt, DP
    Bergström, M
    Savitcheva, I
    Huang, GF
    Estrada, S
    Ausén, B
    Debnath, ML
    Barletta, J
    Price, JC
    Sandell, J
    Lopresti, BJ
    Wall, A
    Koivisto, P
    Antoni, G
    Mathis, CA
    Långström, B
    [J]. ANNALS OF NEUROLOGY, 2004, 55 (03) : 306 - 319
  • [8] Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain
    Klunk, WE
    Wang, YM
    Huang, GF
    Debnath, ML
    Holt, DP
    Mathis, CA
    [J]. LIFE SCIENCES, 2001, 69 (13) : 1471 - 1484
  • [9] 2-(2-[2-dimethylaminothiazol-5-yl]ethenyl)-6-(2-[fluoro]ethoxy)benzoxazole: A novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients
    Kudo, Yukitsuka
    Okamura, Nobuyuki
    Furumoto, Shozo
    Tashiro, Manabu
    Furukawa, Katsutoshi
    Maruyama, Masahiro
    Itoh, Masatoshi
    Iwata, Ren
    Yanai, Kazuhiko
    Arai, Hiroyuki
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2007, 48 (04) : 553 - 561
  • [10] Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease
    Kung, MP
    Hou, C
    Zhuang, ZP
    Skovronsky, D
    Kung, HF
    [J]. BRAIN RESEARCH, 2004, 1025 (1-2) : 98 - 105
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