Synthesis of Indolo[1,2-b]indazole Derivatives via Copper(I)-Catalyzed Intramolecular Amination Reaction

被引：8

作者：

Chi, Jianwen ^{[1
]}

Hang, Chenchen ^{[1
]}

Zhu, Yongming ^{[1
]}

Katayama, Hajime ^{[2
]}

机构：

[1] Soochow Univ, Coll Pharm, Suzhou 215123, Peoples R China

[2] Kinjo Gakuin Univ, Coll Pharm, Nagoya, Aichi, Japan

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Anticancer activity; Cu(I)-catalysis; indolo[1; 2-b]indazole; intramolecular amination; CATALYZED N-ARYLATION; REFRACTORY DISEASES; ARYL HALIDES; INDOLES;

D O I：

10.1080/00397910903043017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile method for preparation of indolo[1,2-b]indazole derivatives was developed by using an intramolecular amination reaction of 1-aminoindoline derivatives in reaction with CuI/PHAN/K2CO3 (250mol%) in 1,4-dioxane at 105 degrees C. The method provides indoles fused with indazole rings in good yields.

引用

页码：1123 / 1133

页数：11

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