Tailored follow-up for early breast cancer patients: A prognostic index that predicts locoregional recurrence

被引:11
作者
van Nes, J. G. H. [1 ]
Putter, H. [2 ]
van Hezewijk, M. [3 ]
Hille, E. T. M. [4 ]
Bartelink, H. [5 ]
Collette, L. [6 ]
van de Velde, C. J. H. [1 ]
机构
[1] Leiden Univ, Med Ctr, Dept Surg, NL-2300 RC Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Dept Med Stat, NL-2300 RC Leiden, Netherlands
[3] Leiden Univ, Med Ctr, Dept Radiat Oncol, NL-2300 RC Leiden, Netherlands
[4] Leiden Univ, Med Ctr, Datactr, NL-2300 RC Leiden, Netherlands
[5] Netherlands Canc Inst, Dept Radiat Oncol, NL-1066 CX Amsterdam, Netherlands
[6] European Org Canc Res & Treatment, B-1200 Brussels, Belgium
来源
EJSO | 2010年 / 36卷 / 07期
关键词
Breast cancer; Locoregional recurrence; Prognostic index; Follow-up; CONSERVING THERAPY; LOCAL RECURRENCE; EUROPEAN ORGANIZATION; TRIAL; SURVIVAL; CHEMOTHERAPY; MASTECTOMY;
D O I
10.1016/j.ejso.2010.05.010
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aims: After treatment, early breast cancer patients undergo follow-up according to standard regimens. After the first year, the main goal is particularly to detect locoregional recurrences (LRR). Our aim was to develop a simple prognostic index to predict LRR to tailor the follow-up programme. Methods: We used data from four large international clinical randomised trials and constructed the prognostic index using Cox proportional hazards regression. The bootstrap (a resampling method) was used for internal validation. Results: A total of 6516 patients treated according to current guidelines with complete covariable information were used for analysis. Covariables important for LRR in patients treated with breast conserving therapy were age, pathological tumour status, boost and surgical margins. The same variables were important for patients treated with a mastectomy, however, instead of the boost, the pathological nodal status was important. The index is composed to consist of three groups based on LRR risk after 10-years. Conclusions: We constructed a simple prognostic index that can be used to estimate risks of LRR in patients with early breast cancer. The prognostic index enables patients to be stratified into three subgroups with different outcomes with regard to LRR. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:617 / 624
页数:8
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