Synthesis of the necine base (-)-supinidine from (S)-glutamic acid

被引：13

作者：

Boynton, CM

Hewson, AT

Mitchell, D

机构：

[1] Sheffield Hallam Univ, Div Chem, Sheffield S1 1WB, S Yorkshire, England

[2] Sheffield Hallam Univ, Biomed Res Ctr, Sheffield S1 1WB, S Yorkshire, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 21期

关键词：

D O I：

10.1039/b005516f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A route is described towards the pyrrolizidine dagger nucleus from derivatives of 5-acetylpyrrolidin-2-one using an intramolecular Wittig reaction with vinylphosphonium salts. The acetoxy ketone 15, derived from (S)-N- benzyloxycarbonylpyroglutamic acid,double dagger affords 16, a known precursor of (-)-supinidine.

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页码：3599 / 3602

页数：4

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