Inducible nitric oxide synthase and control of intracellular bacterial pathogens

被引：221

作者：

Chakravortty, D ^{[1
]}

Hensel, M ^{[1
]}

机构：

[1] FAU Erlangen Nurnberg, Inst Klin Mikrobiol Immunol & Hyg, D-91054 Erlangen, Germany

来源：

MICROBES AND INFECTION | 2003年 / 5卷 / 07期

关键词：

NO; iNOS; intracellular parasitism; innate immunity; SALMONELLA-TYPHIMURIUM INFECTION; PHAGOCYTE NADPH-OXIDASE; MYCOBACTERIUM-TUBERCULOSIS; LEGIONELLA-PNEUMOPHILA; MOUSE MACROPHAGES; INTERFERON-GAMMA; ESCHERICHIA-COLI; HOST-DEFENSE; IN-VIVO; MICE;

D O I：

10.1016/S1286-4579(03)00096-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inducible nitric oxide synthase (iNOS) has important functions in innate immunity and regulation of immune functions. Here, the role of iNOS in the pathogenesis of various intracellular bacterial infections is discussed. These pathogens have also evolved a broad array of strategies to repair damage by reactive nitrogen intermediates, and to suppress or inhibit functions of iNOS. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：621 / 627

页数：7

共 55 条

[1] Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities [J].

Alam, MS ;

Akaike, T ;

Okamoto, S ;

Kubota, T ;

Yoshitake, J ;

Sawa, T ;

Miyamoto, Y ;

Tamura, F ;

Maeda, H .

INFECTION AND IMMUNITY, 2002, 70 (06) :3130-3142

[2] PRODUCTION OF NITRIC-OXIDE AND SUPEROXIDE BY ACTIVATED MACROPHAGES AND KILLING OF LEISHMANIA-MAJOR [J].

ASSREUY, J ;

CUNHA, FQ ;

EPPERLEIN, M ;

NORONHADUTRA, A ;

ODONNELL, CA ;

LIEW, FY ;

MONCADA, S .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (03) :672-676

[3] Nitric oxide and the immune response [J].

Bogdan, C .

NATURE IMMUNOLOGY, 2001, 2 (10) :907-916

[4] Peroxynitrite reductase activity of bacterial peroxiredoxins [J].

Bryk, R ;

Griffin, P ;

Nathan, C .

NATURE, 2000, 407 (6801) :211-215

[5] Salmonella pathogenicity island 2 mediates protection of intracellular Salmonella from reactive nitrogen intermediates [J].

Chakravortty, D ;

Hansen-Wester, I ;

Hensel, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (09) :1155-1166

[6] What is the role of nitric oxide in murine and human host defense against tuberculosis? Current knowledge [J].

Chan, ED ;

Chan, J ;

Schluger, NW .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2001, 25 (05) :606-612

[7]

Chen BJ, 1996, FEMS IMMUNOL MED MIC, V14, P109, DOI 10.1016/0928-8244(96)00018-1

[8] Salmonella enterica serovar typhimurium-dependent regulation of inducible nitric oxide synthase expression in macrophages by invasins SipB, SipC, and SipD and effector SopE2 [J].

Cherayil, BJ ;

McCormick, BA ;

Bosley, J .

INFECTION AND IMMUNITY, 2000, 68 (10) :5567-5574

[9] IFN-γ and NO in mycobacterial disease:: new jobs for old hands [J].

Cooper, AM ;

Adams, LB ;

Dalton, DK ;

Appelberg, R ;

Ehlers, S .

TRENDS IN MICROBIOLOGY, 2002, 10 (05) :221-226

[10] Expression of the nitric oxide synthase 2 gene is not essential for early control of Mycobacterium tuberculosis in the murine lung [J].

Cooper, AM ;

Pearl, JE ;

Brooks, JV ;

Ehlers, S ;

Orme, IM .

INFECTION AND IMMUNITY, 2000, 68 (12) :6879-6882

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