In vitro activity of oritavancin against Gram-positive pathogens isolated in Canadian hospital laboratories from 2011 to 2013

被引：10
|
作者：
Karlowsky, J. A. [1 ]
Walkty, A. J. [1 ]
Baxter, M. R. [1 ]
Adam, H. J. [1 ]
Zhanel, G. G. [1 ]
机构：
[1] Univ Manitoba, Fac Med, Dept Med Microbiol & Infect Dis, Winnipeg, MB, Canada
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2014年 / 80卷 / 04期
关键词：
Oritavancin; MRSA; Skin and soft tissue infection; RESISTANT STAPHYLOCOCCUS-AUREUS; INFECTIONS; SKIN;
D O I：
10.1016/j.diagmicrobio.2014.09.003
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Gram-positive pathogens isolated in 15 Canadian hospital laboratories between 2011 and 2013 were tested for susceptibility to oritavancin and comparative antimicrobial agents using the Clinical and Laboratory Standards Institute broth microdilution method. Oritavancin demonstrated in vitro activity equivalent to, or more potent than, vancomycin, daptomycin, linezolid, and tigecycline against the isolates of methicillin-susceptible Staphylococcus aureus (n = 1460; oritavancin MIC90, 0.06 mu g/mL; 99.7% oritavancin-susceptible), methicillin-resistant S. aureus (n = 427; oritavancin MIC90, 0.06 mu g/mL; 99.5% oritavancin-susceptible), Streptococcus pyogenes (n = 132; oritavancin MIC90, 0.25 mu g/mL; 99.2% oritavancin-susceptible), Streptococcus agalactiae (n = 156; oritavancin MIC90, 0.12 mu g/mL; 100% oritavancin-susceptible), and Enterococcus faecalis (n = 304; oritavancin MIC90, 0.06 mu g/mL; 98.7% oritavancin-susceptible) tested. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：311 / 315
页数：5
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