Parkinson's disease;
biomarkers;
individualized treatment;
response inhibition;
impulse control disorders;
CATECHOL-O-METHYLTRANSFERASE;
IMPULSE CONTROL DISORDERS;
DEEP BRAIN-STIMULATION;
TRANSCRANIAL MAGNETIC STIMULATION;
RESONANCE-IMAGING MARKERS;
MEDIAL PREFRONTAL CORTEX;
BIMANUAL COORDINATION;
DOPAMINERGIC MODULATION;
VAL(158)MET GENOTYPE;
6-HYDROXYDOPAMINE LESIONS;
D O I:
10.1080/00222895.2014.941784
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
. Parkinson's disease (Pd) is the second most prevalent degenerative neurological condition worldwide. Improving and sustaining quality of life is an important goal for Parkinson's patients. Key areas of focus to achieve this goal include earlier diagnosis and individualized treatment. In this review the authors discuss impulse control in Pd and examine how measures of impulse control from a response inhibition task may provide clinically useful information (a) within an objective test battery to aid earlier diagnosis of Pd and (b) in postdiagnostic Pd, to better identify individuals at risk of developing impulse control disorders with dopaminergic medication.
机构:
UCL, Inst Neurol, Cognit Motor Neurosci Grp, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Natl Hosp Neurol & Neurosurg, London WC1N 3BG, EnglandUCL, Inst Neurol, Cognit Motor Neurosci Grp, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Obeso, Ignacio
Wilkinson, Leonora
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机构:
UCL, Inst Neurol, Cognit Motor Neurosci Grp, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Natl Hosp Neurol & Neurosurg, London WC1N 3BG, EnglandUCL, Inst Neurol, Cognit Motor Neurosci Grp, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Wilkinson, Leonora
Jahanshahi, Marjan
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Inst Neurol, Cognit Motor Neurosci Grp, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Natl Hosp Neurol & Neurosurg, London WC1N 3BG, EnglandUCL, Inst Neurol, Cognit Motor Neurosci Grp, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
机构:
UCL, Inst Neurol, Cognit Motor Neurosci Grp, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Natl Hosp Neurol & Neurosurg, London WC1N 3BG, EnglandUCL, Inst Neurol, Cognit Motor Neurosci Grp, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Obeso, Ignacio
Wilkinson, Leonora
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Inst Neurol, Cognit Motor Neurosci Grp, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Natl Hosp Neurol & Neurosurg, London WC1N 3BG, EnglandUCL, Inst Neurol, Cognit Motor Neurosci Grp, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Wilkinson, Leonora
Jahanshahi, Marjan
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Inst Neurol, Cognit Motor Neurosci Grp, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Natl Hosp Neurol & Neurosurg, London WC1N 3BG, EnglandUCL, Inst Neurol, Cognit Motor Neurosci Grp, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England