Does Response Inhibition Have Pre- and Postdiagnostic Utility in Parkinson's Disease?

被引：14

作者：

MacDonald, Hayley J. ^{[1
,2
]}

Byblow, Winston D. ^{[1
,2
]}

机构：

[1] Univ Auckland, Dept Sport & Exercise Sci, Private Bag 92019, Auckland 1142, New Zealand

[2] Univ Auckland, Ctr Brain Res, Auckland 1, New Zealand

来源：

JOURNAL OF MOTOR BEHAVIOR | 2015年 / 47卷 / 01期

关键词：

Parkinson's disease; biomarkers; individualized treatment; response inhibition; impulse control disorders; CATECHOL-O-METHYLTRANSFERASE; IMPULSE CONTROL DISORDERS; DEEP BRAIN-STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; RESONANCE-IMAGING MARKERS; MEDIAL PREFRONTAL CORTEX; BIMANUAL COORDINATION; DOPAMINERGIC MODULATION; VAL(158)MET GENOTYPE; 6-HYDROXYDOPAMINE LESIONS;

D O I：

10.1080/00222895.2014.941784

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

. Parkinson's disease (Pd) is the second most prevalent degenerative neurological condition worldwide. Improving and sustaining quality of life is an important goal for Parkinson's patients. Key areas of focus to achieve this goal include earlier diagnosis and individualized treatment. In this review the authors discuss impulse control in Pd and examine how measures of impulse control from a response inhibition task may provide clinically useful information (a) within an objective test battery to aid earlier diagnosis of Pd and (b) in postdiagnostic Pd, to better identify individuals at risk of developing impulse control disorders with dopaminergic medication.

引用

页码：29 / 45

页数：17

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