Antipruritic application of ovocystatin in atopic dermatitis in dogs - preliminary study

被引：0

作者：

Popiel, Jaroslaw ^{[1
]}

Cekiera, Agnieszka

Kurosad, Agnieszka

Paslawska, Urszula

Noszczyk-Nowak, Agnieszka

Nicpon, Jozef

机构：

[1] Wroclaw Univ Environm & Life Sci, Dept Internal Med, PL-50366 Wroclaw, Poland

来源：

BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY | 2014年 / 58卷 / 04期

关键词：

dogs; ovocystatin; pruritus; atopic dermatitis; EGG-WHITE; TACROLIMUS OINTMENT; SEVERITY SCALE; TASK-FORCE; CYSTATIN; INHIBITOR; PRURITUS; VALIDATION; CADESI-03; EFFICACY;

D O I：

10.2478/bvip-2014-0097

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The study was an attempt to determine the possibilities of using ovocystatin, a component of a new generation product of natural origin, in local therapy of atopic dermatitis in dogs by suppressing pruritus during illness. Chicken egg cystatin was used locally in the interdigital spaces of forelimbs of dogs used in the experiment. The degree of pruritus and clinical changes in the animals were defined using CADESI-03 scale before and after the beginning of the experiment. The results obtained proved that ovocystatin may be used as a substance suppressing pruritus in atopic dermatitis.

引用

页码：639 / 643

页数：5

共 25 条

[1] CYSTATIN, A PROTEIN INHIBITOR OF CYSTEINE PROTEINASES - IMPROVED PURIFICATION FROM EGG-WHITE, CHARACTERIZATION, AND DETECTION IN CHICKEN SERUM [J].

ANASTASI, A ;

BROWN, MA ;

KEMBHAVI, AA ;

NICKLIN, MJH ;

SAYERS, CA ;

SUNTER, DC ;

BARRETT, AJ .

BIOCHEMICAL JOURNAL, 1983, 211 (01) :129-138

[2]

BARRETT AJ, 1981, METHOD ENZYMOL, V80, P771

[3] Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded randomized controlled trial [J].

Bensignor, E ;

Olivry, T .

VETERINARY DERMATOLOGY, 2005, 16 (01) :52-60

[4] The ACVD task force on canine atopic dermatitis (XV): fundamental concepts in clinical diagnosis [J].

DeBoer, DJ ;

Hillier, A .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2001, 81 (3-4) :271-276

[5]

DERIE MA, 1991, ACTA DERM-VENEREOL, V71, P452

[6] A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis [J].

Favrot, Claude ;

Steffan, Jean ;

Seewald, Wolfgang ;

Picco, Federicca .

VETERINARY DERMATOLOGY, 2010, 21 (01) :23-30

[7]

Golab K, 2012, PRZEM CHEM, V91, P741

[8]

Got4b K, 2005, Adv Clin Exp Med, V14, P1001

[9] Subepidermal bullous dermatosis due to topical corticosteroid therapy in dogs [J].

Gross, TL ;

Walder, EJ ;

Ihrke, PJ .

VETERINARY DERMATOLOGY, 1997, 8 (02) :127-131

[10] Development of an owner-assessed scale to measure the severity of pruritus in dogs [J].

Hill, P. B. ;

Lau, P. ;

Rybnicek, J. .

VETERINARY DERMATOLOGY, 2007, 18 (05) :301-308

← 1 2 3 →