Intradermal Administration of Fractional Doses of Inactivated Poliovirus Vaccine: A Dose-Sparing Option for Polio Immunization

被引：49

作者：

Okayasu, Hiromasa ^{[1
]}

Sein, Carolyn ^{[1
]}

Blanc, Diana Chang ^{[2
]}

Gonzalez, Alejandro Ramirez ^{[2
]}

Zehrung, Darin ^{[3
]}

Jarrahian, Courtney ^{[3
]}

Macklin, Grace ^{[1
]}

Sutter, Roland W. ^{[1
]}

机构：

[1] WHO, Res Policy & Containment Polio Eradicat Dep, Ave Appia 20, CH-1211 Geneva, Switzerland

[2] WHO, Immunizat Vaccines & Biol Dept, Expanded Programme Immunizat, Geneva, Switzerland

[3] PATH, Seattle, WA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2017年 / 216卷

基金：

比尔及梅琳达.盖茨基金会;

关键词：

fractional; polio; vaccine; intradermal vaccination; inactivated polio vaccine; vaccination; RANDOMIZED CONTROLLED-TRIAL; MICRONEEDLE DEVICE; IMMUNE-RESPONSE; HEALTHY-ADULTS; IMMUNOGENICITY; DELIVERY; NEEDLE; EFFICACY; INFANTS; SAFETY;

D O I：

10.1093/infdis/jix038

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A fractional dose of inactivated poliovirus vaccine (fIPV) administered by the intradermal route delivers one fifth of the full vaccine dose administered by the intramuscular route and offers a potential dose-sparing strategy to stretch the limited global IPV supply while further improving population immunity. Multiple studies have assessed immunogenicity of intradermal fIPV compared with the full intramuscular dose and demonstrated encouraging results. Novel intradermal devices, including intradermal adapters and disposable-syringe jet injectors, have also been developed and evaluated as alternatives to traditional Bacillus Calmette-Guerin needles and syringes for the administration of fIPV. Initial experience in India, Pakistan, and Sri Lanka suggests that it is operationally feasible to implement fIPV vaccination on a large scale. Given the available scientific data and operational feasibility shown in early-adopter countries, countries are encouraged to consider introducing a fIPV strategy into their routine immunization and supplementary immunization activities.

引用

页码：S161 / S167

页数：7

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