Suppression of experimental allergic encephalomyelitis is specific to the frequency and intensity of nocturnally applied, intermittent magnetic fields in rats

被引:6
作者
Cook, LL
Persinger, MA [1 ]
机构
[1] Laurentian Univ, Behav Neurosci Lab, Sudbury, ON P3E 2C6, Canada
[2] Laurentian Univ, Dept Biol, Sudbury, ON P3E 2C6, Canada
关键词
magnetic fields; experimental allergic encephalomyelitis; rat; multiple sclerosis; nocturnal exposures; NanoTesla range; amplitude modulations;
D O I
10.1016/S0304-3940(00)01454-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Female Lewis rats (n = 72) were inoculated with an emulsion of spinal cord and complete Freund's adjuvant. They were then exposed for approximately 6 min every hour between midnight and 08:00 h for 2 weeks to either 7 or 40 Hz amplitude-modulated magnetic fields whose temporal pattern was designed to simulate a (geomagnetic) storm sudden commencement. The peak strengths of the fields averaged between either 30-50 nT (low intensity) or 500 nT thigh intensity). Rats exposed to the 7 Hz, low intensity magnetic fields displayed significantly less severe overt signs of experimental allergic encephalomyelitis than rats exposed to either of the two intensities of the 40 Hz fields, the high intensity 7 Hz field, or the reference (<10 nT) condition. The latter groups did not differ significantly from each other. Predicted severity based upon the numbers of foci of infiltrations of lymphocytes within the brains of the rats also demonstrated the ameliorating effects of the low intensity, 7 Hz exposures. These results suggest very specific characteristics of complex, weak magnetic fields within the sleeping environment could affect the symptoms of autoimmunity. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码:171 / 174
页数:4
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