Immunohistochemical expression of angiogenesis-related markers in oral squamous cell carcinomas with multiple metastatic lymph nodes

被引：28
作者：
Nikitakis, NG
Rivera, H
Lopes, MA
Siavash, H
Reynolds, MA
Ord, RA
Sauk, JJ
机构：
[1] Univ Maryland, Sch Dent, Dept Diagnost Sci & Pathol, Baltimore, MD 21201 USA
[2] Univ Maryland, Dept Periodont, Baltimore, MD 21201 USA
[3] Univ Maryland, Dept Oral & Maxillofacial Surg, Baltimore, MD 21201 USA
[4] Univ Maryland, Greenebaum Canc Ctr, Baltimore, MD 21201 USA
[5] Cent Univ Venezuela, Oral Pathol Lab, Fac Dent, Caracas, Venezuela
[6] Univ Estadual Campinas, Dept Oral Diag, Sch Dent Piracicaba, Sao Paulo, Brazil
来源：
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2003年 / 119卷 / 04期
关键词：
angiogenesis; oral; squamous; carcinoma; metastasis; collagen XVIII; endostatin; HSP47; cathepsin L;
D O I：
10.1309/JD3DHGCDGAUN1R0J
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The aim of this study was to evaluate the histopathologic features and the expression of angiogenesis-related markers in primary tumors and metastatic lymph nodes of oral squamous cell carcinomas (SCCs) with multiple lymph node involvement in comparison with oral SCCs without nodal metastasis. The protein levels of the angiogenesis inhibitor endostatin, as well as those of the related molecules collagen XVIII, collagen-binding protein (CBP) 2/heat shock protein (HSP) 4 7, and cathepsin L, were evaluated by inununohistochemical analysis. Compared with nonmetastatic cases, primary tumors of the metastatic group exhibited significantly decreased protein levels of endostatin and its precursor collagen XVIII. Comparison between primary tumors and positive nodes of the metastatic cases revealed decreased expression of collagen XVIII and CBP2/HSP47 in metastases. Angiogenesis is essential for tumor growth and metastasis; accordingly, the observed differences in the immunohistochemical expression of angiogenesis-related proteins in oral SCC with multiple lymph node involvement may provide an explanation for the increased metastatic potential of these tumors.
引用
收藏
页码：574 / 586
页数：13
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