Pharmacological DNA demethylation: Implications for cancer immunotherapy

被引：25

作者：

Roulois, David ^{[1
]}

Yau, Helen Loo ^{[1
,2
]}

De Carvalho, Daniel D. ^{[1
,2
]}

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada

[2] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

来源：

ONCOIMMUNOLOGY | 2016年 / 5卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

5-AZA-CdR; colorectal cancer; DNA methylation; decitabine; epigenetic therapy; CELLS;

D O I：

10.1080/2162402X.2015.1090077

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies have demonstrated that DNA demethylation agents can mimic a viral infection by induction of dsRNAs. This viral mimicry leads to an antiviral response mediated by the cytosolic pattern recognition receptor MDA5, followed by MAVS (IPS1) activation, IRF7 nuclear translocation and upregulation of type III Interferon and interferon-stimulated genes.

引用

页数：3

共 9 条

[1] Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10 [J].

Burkart, Christoph ;

Arimoto, Kei-ichiro ;

Tang, Tingdong ;

Cong, Xiuli ;

Xiao, Nengming ;

Liu, Yun-Cai ;

Kotenko, Sergei V. ;

Ellies, Lesley G. ;

Zhang, Dong-Er .

EMBO MOLECULAR MEDICINE, 2013, 5 (07) :1035-1050

[2] Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses [J].

Chiappinelli, Katherine B. ;

Strissel, Pamela L. ;

Desrichard, Alexis ;

Li, Huili ;

Henke, Christine ;

Akman, Benjamin ;

Hein, Alexander ;

Rote, Neal S. ;

Cope, Leslie M. ;

Snyder, Alexandra ;

Makarov, Vladimir ;

Buhu, Sadna ;

Slamon, Dennis J. ;

Wolchok, Jedd D. ;

Pardoll, Drew M. ;

Beckmann, Matthias W. ;

Zahnow, Cynthia A. ;

Mergoub, Taha ;

Chan, Timothy A. ;

Baylin, Stephen B. ;

Strick, Reiner .

CELL, 2015, 162 (05) :974-986

[3]

Griffiths DJ, 2001, GENOME BIOL, V2

[4] Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer [J].

Juergens, Rosalyn A. ;

Wrangle, John ;

Vendetti, Frank P. ;

Murphy, Sara C. ;

Zhao, Ming ;

Coleman, Barbara ;

Sebree, Rosa ;

Rodgers, Kristen ;

Hooker, Craig M. ;

Franco, Noreli ;

Lee, Beverly ;

Tsai, Salina ;

Delgado, Igor Espinoza ;

Rudek, Michelle A. ;

Belinsky, Steven A. ;

Herman, James G. ;

Baylin, Stephen B. ;

Brock, Malcolm V. ;

Rudin, Charles M. .

CANCER DISCOVERY, 2011, 1 (07) :598-607

[5] Epigenetic modifications as therapeutic targets [J].

Kelly, Theresa K. ;

De Carvalho, Daniel D. ;

Jones, Peter A. .

NATURE BIOTECHNOLOGY, 2010, 28 (10) :1069-1078

[6] Self-renewal as a therapeutic target in human colorectal cancer [J].

Kreso, Antonija ;

van Galen, Peter ;

Pedley, Nicholas M. ;

Lima-Fernandes, Evelyne ;

Frelin, Catherine ;

Davis, Thomas ;

Cao, Liangxian ;

Baiazitov, Ramil ;

Du, Wu ;

Sydorenko, Nadiya ;

Moon, Young-Choon ;

Gibson, Lianne ;

Wang, Yadong ;

Leung, Cherry ;

Iscove, Norman N. ;

Arrowsmith, Cheryl H. ;

Szentgyorgyi, Eva ;

Gallinger, Steven ;

Dick, John E. ;

O'Brien, Catherine A. .

NATURE MEDICINE, 2014, 20 (01) :29-+

[7] Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer [J].

Kreso, Antonija ;

O'Brien, Catherine A. ;

van Galen, Peter ;

Gan, Olga I. ;

Notta, Faiyaz ;

Brown, Andrew M. K. ;

Ng, Karen ;

Ma, Jing ;

Wienholds, Erno ;

Dunant, Cyrille ;

Pollett, Aaron ;

Gallinger, Steven ;

McPherson, John ;

Mullighan, Charles G. ;

Shibata, Darryl ;

Dick, John E. .

SCIENCE, 2013, 339 (6119) :543-548

[8] DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts [J].

Roulois, David ;

Yau, Helen Loo ;

Singhania, Rajat ;

Wang, Yadong ;

Danesh, Arnavaz ;

Shen, Shu Yi ;

Han, Han ;

Liang, Gangning ;

Jones, Peter A. ;

Pugh, Trevor J. ;

O'Brien, Catherine ;

De Carvalho, Daniel D. .

CELL, 2015, 162 (05) :961-973

[9] Guarding the frontiers: the biology of type III interferons [J].

Wack, Andreas ;

Terczynska-Dyla, Ewa ;

Hartmann, Rune .

NATURE IMMUNOLOGY, 2015, 16 (08) :802-809

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