Treatment of primary angiitis of the central nervous system in childhood with mycophenolate mofetil

被引：31
|
作者：
Sen, Ethan S. [1 ]
Leone, Valentina [2 ]
Abinun, Mario [2 ]
Forsyth, Robert [2 ]
Ramesh, Venkateswaran [2 ]
Friswell, Mark [2 ]
O'Callaghan, Finbar [1 ]
Ramanan, Athimalaipet V. [1 ]
机构：
[1] Bristol Royal Hosp Children, Dept Paediat Rheumatol & Neurol, Bristol BS2 8BJ, Avon, England
[2] Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England
来源：
RHEUMATOLOGY | 2010年 / 49卷 / 04期
关键词：
CNS vasculitis; Mycophenolate mofetil; LUPUS-ERYTHEMATOSUS; VASCULITIS; CHILDREN; ANGIOGRAPHY; PATIENT; DISEASE;
D O I：
10.1093/rheumatology/kep453
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective. To assess the use of mycophenolate mofetil (MMF) in the treatment of refractory primary angiitis of the CNS in childhood (cPACNS). Methods. A retrospective chart review was performed in patients with cPACNS who were treated with MMF following failure of a combination of corticosteroids and another immunosuppressant. Results. Three patients from two centres were included in this study. The age of onset of disease was 5, 6 and 9 years. All the patients improved when treated with MMF, such that the dose of corticosteroids could be weaned or stopped. Conclusions. MMF should be considered for maintenance treatment in the management of patients with cPACNS refractory to the combination of corticosteroids and first-line immunosuppressive agents.
引用
收藏
页码：806 / 811
页数：6
相关论文
共 50 条
  • [41] Cerebellar Infarction Caused by Primary Central Nervous System Angiitis of Childhood: Case Report
    Murakami, Mamoru
    Ikeda, Yukio
    Haraoka, Jo
    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2010, 19 (01) : 77 - 80
  • [42] Primary Angiitis of the Central Nervous System: Diagnostic Criteria
    Powers, William J.
    NEUROLOGIC CLINICS, 2015, 33 (02) : 515 - +
  • [43] Unilateral hemispheric primary angiitis of the central nervous system
    Ho, Michael G.
    Chai, Wanxing
    Vinters, Harry V.
    Hathout, Gasser
    Mishra, Shri
    Yim, Catherine
    Valdes-Sueiras, Miguel
    Nishimura, Robert
    JOURNAL OF NEUROLOGY, 2011, 258 (09) : 1714 - 1716
  • [44] Primary angiitis of the central nervous system at conventional angiography
    Kadkhodayan, Y
    Alreshaid, A
    Moran, CJ
    Cross, DT
    Powers, WJ
    Derdeyn, CP
    RADIOLOGY, 2004, 233 (03) : 878 - 882
  • [45] An illustrative case of primary angiitis of the central nervous system
    Shiner, Elizabeth A.
    Zagami, Alessandro S.
    SAGE OPEN MEDICAL CASE REPORTS, 2014, 2
  • [46] Primary angiitis of the central nervous system: a case report
    Yu Xiao-lin
    Liu Ai-fen
    Ma Lin
    Yan Chuan-zhu
    Zhao Yu-ying
    Shan Pei-yan
    CHINESE MEDICAL JOURNAL, 2011, 124 (17) : 2782 - 2785
  • [47] Unilateral hemispheric primary angiitis of the central nervous system
    Michael G. Ho
    Wanxing Chai
    Harry V. Vinters
    Gasser Hathout
    Shri Mishra
    Catherine Yim
    Miguel Valdes-Sueiras
    Robert Nishimura
    Journal of Neurology, 2011, 258 : 1714 - 1716
  • [48] PRIMARY ANGIITIS OF THE CENTRAL NERVOUS SYSTEM - A DIAGNOSTIC CHALLENGE
    Mitrovic, Josko
    Golob, Majda
    Lazibat, Ines
    ACTA CLINICA CROATICA, 2023, 62 (02) : 355 - 361
  • [49] Primary Angiitis of the Central Nervous System: A Great Mimicker
    Modi, Tanish
    Modi, Manish
    ANNALS OF INDIAN ACADEMY OF NEUROLOGY, 2022, 25 (06) : 989 - 990
  • [50] Biopsy Findings in Primary Angiitis of the Central Nervous System
    Miller, Dylan V.
    Salvarani, Carlo
    Hunder, Gene G.
    Brown, Robert D.
    Parisi, Joseph E.
    Christianson, Teresa J.
    Giannini, Caterina
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2009, 33 (01) : 35 - 43
12345