L-Proline-catalyzed one-pot expeditious synthesis of highly substituted pyridines at room temperature

被引：66
作者：
Mukhopadhyay, Chhanda [1 ]
Tapaswi, Pradip Kumar [1 ]
Butcher, Ray J. [2 ]
机构：
[1] Univ Calcutta, Dept Chem, Kolkata 700009, India
[2] Howard Univ, Dept Chem, Washington, DC 20059 USA
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 13期
关键词：
L-Proline; Substituted pyridines; Room temperature; Organocatalyst; SOLVENT-FREE SYNTHESIS; EFFICIENT SYNTHESIS; BIGINELLI REACTION; MANNICH REACTION; 2,4,6-TRIARYLPYRIDINES; ALDEHYDES; ACID; PEG; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; ALLYLATION;
D O I：
10.1016/j.tetlet.2010.01.106
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Only 15 mol% of L-proline in ethanol proved to be a very efficient catalyst for the one-pot synthesis of a wide variety of highly substituted pyridines at room temperature. The methodology is mild, efficient, high yielding, and the products Call be directly recrystallized from hot ethanol. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1797 / 1802
页数：6
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