An elevated serum urate concentration is associated with kidney damage. Men's uric acid levels are usually higher than women's. However, postmenopausal women have a higher risk of gout than men, and comorbidities are also higher than in men. This study examined the sex differences in the relationship between hyperuricemia and renal progression in early chronic kidney disease (CKD) and non-CKD, and further examined the incidence of CKD in non-CKD populations among patients over 50 years of age. We analyzed 1856 women and 1852 men participating in the epidemiology and risk factors surveillance of the CKD database. Women showed a significantly higher risk of renal progression and CKD than men within the hyperuricemia group. After adjusting covariates, women, but not men resulted in an hazard ratio (HR) for developing renal progression (HR = 1.12; 95% CI 1.01-1.24 in women and HR = 1.03; 95% CI 0.93-1.13 in men) and CKD (HR = 1.11; 95% CI 1.01-1.22 in women and HR = 0.95; 95% CI 0.85-1.05 in men) for each 1 mg/dL increase in serum urate levels. The association between serum urate levels and renal progression was stronger in women. Given the prevalence and impact of kidney disease, factors that impede optimal renal function management in women and men must be identified to provide tailored treatment recommendations.
机构:
Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland
Univ Helsinki, Abdominal Ctr Nephrol, Helsinki, Finland
Helsinki Univ Hosp, Helsinki, Finland
Univ Helsinki, Res Program Unit, Diabet & Obes, Helsinki, FinlandFolkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland
Ahola, Aila J.
;
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机构:
Sandholm, Niina
;
Forsblom, Carol
论文数: 0引用数: 0
h-index: 0
机构:
Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland
Univ Helsinki, Abdominal Ctr Nephrol, Helsinki, Finland
Helsinki Univ Hosp, Helsinki, Finland
Univ Helsinki, Res Program Unit, Diabet & Obes, Helsinki, FinlandFolkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland
Forsblom, Carol
;
论文数: 引用数:
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机构:
Harjutsalo, Valma
;
Dahlstrom, Emma
论文数: 0引用数: 0
h-index: 0
机构:
Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland
Univ Helsinki, Abdominal Ctr Nephrol, Helsinki, Finland
Helsinki Univ Hosp, Helsinki, Finland
Univ Helsinki, Res Program Unit, Diabet & Obes, Helsinki, FinlandFolkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland
机构:
King Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
King Saud Univ, Dept Biochem, Coll Sci, Prince Mutaib Chair Biomarkers Osteoporosis, Riyadh 11451, Saudi ArabiaKing Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
Al-Daghri, Nasser M.
;
论文数: 引用数:
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机构:
Al-Attas, Omar S.
;
Wani, Kaiser
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
King Saud Univ, Dept Biochem, Coll Sci, Prince Mutaib Chair Biomarkers Osteoporosis, Riyadh 11451, Saudi ArabiaKing Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
Wani, Kaiser
;
Sabico, Shaun
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
King Saud Univ, Dept Biochem, Coll Sci, Prince Mutaib Chair Biomarkers Osteoporosis, Riyadh 11451, Saudi ArabiaKing Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
Sabico, Shaun
;
Alokail, Majed S.
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
King Saud Univ, Dept Biochem, Coll Sci, Prince Mutaib Chair Biomarkers Osteoporosis, Riyadh 11451, Saudi ArabiaKing Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
机构:
St George Hosp, Dept Renal Med, Sydney, NSW, Australia
George Inst Global Hlth, Renal & Metab Div, Level 5,1 King St, Newtown, NSW 2042, Australia
Univ Queensland, Australasian Kidney Trials Network, Brisbane, Qld, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Badve, Sunil V.
;
论文数: 引用数:
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机构:
Pascoe, Elaine M.
;
Biostat, M.
论文数: 0引用数: 0
h-index: 0
机构:St George Hosp, Dept Renal Med, Sydney, NSW, Australia
Biostat, M.
;
Tiku, Anushree
论文数: 0引用数: 0
h-index: 0
机构:
St George Hosp, Dept Renal Med, Sydney, NSW, Australia
George Inst Global Hlth, Renal & Metab Div, Level 5,1 King St, Newtown, NSW 2042, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Tiku, Anushree
;
论文数: 引用数:
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机构:
Boudville, Neil
;
Brown, Fiona G.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Monash Med Ctr, Dept Nephrol, Melbourne, Vic, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Brown, Fiona G.
;
Cass, Alan
论文数: 0引用数: 0
h-index: 0
机构:
Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Cass, Alan
;
Clarke, Philip
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, Nuffield Dept Populat Hlth, Hlth Econ Res Ctr, Oxford, EnglandSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Clarke, Philip
;
Dalbeth, Nicola
论文数: 0引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Med, Auckland, New ZealandSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Dalbeth, Nicola
;
Day, Richard O.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Clin Sch, Sydney, NSW, Australia
Univ New South Wales Med, Dept Clin Pharmacol, Sydney, NSW, Australia
Univ New South Wales Med, Dept Toxicol, Sydney, NSW, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Day, Richard O.
;
de Zoysa, Janak R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Med, Auckland, New Zealand
Waitemata Dist Hlth Board, Renal Serv, Auckland, New ZealandSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
de Zoysa, Janak R.
;
Douglas, Bettina
论文数: 0引用数: 0
h-index: 0
机构:
Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Douglas, Bettina
;
Faull, Randall
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Adelaide, SA, Australia
Cent Northern Adelaide Renal & Transplantat Serv, Adelaide, SA, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Faull, Randall
;
Harris, David C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, St Vincents Hosp, Ctr Transplant & Renal Res, Westmead Inst Med Res, Sydney, NSW, Australia
Westmead Hosp, Western Sydney Local Hlth Dist, Dept Renal Med, Sydney, NSW, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Harris, David C.
;
Hawley, Carmel M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Australasian Kidney Trials Network, Brisbane, Qld, Australia
Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Hawley, Carmel M.
;
Jones, Graham R. D.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Clin Sch, Sydney, NSW, Australia
SydPath, Chem Pathol, Sydney, NSW, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Jones, Graham R. D.
;
Kanellis, John
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Monash Med Ctr, Dept Nephrol, Melbourne, Vic, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Kanellis, John
;
Palmer, Suetonia C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Otago Christchurch, Dept Med, Christchurch, New ZealandSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Palmer, Suetonia C.
;
Perkovic, Vlado
论文数: 0引用数: 0
h-index: 0
机构:
George Inst Global Hlth, Renal & Metab Div, Level 5,1 King St, Newtown, NSW 2042, Australia
Royal North Shore Hosp, Dept Nephrol, Sydney, NSW, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Perkovic, Vlado
;
Rangan, Gopala K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, St Vincents Hosp, Ctr Transplant & Renal Res, Westmead Inst Med Res, Sydney, NSW, Australia
Westmead Hosp, Western Sydney Local Hlth Dist, Dept Renal Med, Sydney, NSW, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Rangan, Gopala K.
;
论文数: 引用数:
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机构:
Reidlinger, Donna
;
Robison, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Australasian Kidney Trials Network, Brisbane, Qld, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Robison, Laura
;
Walker, Robert J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Otago, Dunedin Sch Med, Dunedin, New ZealandSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Walker, Robert J.
;
论文数: 引用数:
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机构:
Walters, Giles
;
Johnson, David W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Australasian Kidney Trials Network, Brisbane, Qld, Australia
Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, Australia
Translat Res Inst, Brisbane, Qld, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
机构:
Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland
Univ Helsinki, Abdominal Ctr Nephrol, Helsinki, Finland
Helsinki Univ Hosp, Helsinki, Finland
Univ Helsinki, Res Program Unit, Diabet & Obes, Helsinki, FinlandFolkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland
Ahola, Aila J.
;
论文数: 引用数:
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机构:
Sandholm, Niina
;
Forsblom, Carol
论文数: 0引用数: 0
h-index: 0
机构:
Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland
Univ Helsinki, Abdominal Ctr Nephrol, Helsinki, Finland
Helsinki Univ Hosp, Helsinki, Finland
Univ Helsinki, Res Program Unit, Diabet & Obes, Helsinki, FinlandFolkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland
Forsblom, Carol
;
论文数: 引用数:
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机构:
Harjutsalo, Valma
;
Dahlstrom, Emma
论文数: 0引用数: 0
h-index: 0
机构:
Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland
Univ Helsinki, Abdominal Ctr Nephrol, Helsinki, Finland
Helsinki Univ Hosp, Helsinki, Finland
Univ Helsinki, Res Program Unit, Diabet & Obes, Helsinki, FinlandFolkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland
机构:
King Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
King Saud Univ, Dept Biochem, Coll Sci, Prince Mutaib Chair Biomarkers Osteoporosis, Riyadh 11451, Saudi ArabiaKing Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
Al-Daghri, Nasser M.
;
论文数: 引用数:
h-index:
机构:
Al-Attas, Omar S.
;
Wani, Kaiser
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
King Saud Univ, Dept Biochem, Coll Sci, Prince Mutaib Chair Biomarkers Osteoporosis, Riyadh 11451, Saudi ArabiaKing Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
Wani, Kaiser
;
Sabico, Shaun
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
King Saud Univ, Dept Biochem, Coll Sci, Prince Mutaib Chair Biomarkers Osteoporosis, Riyadh 11451, Saudi ArabiaKing Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
Sabico, Shaun
;
Alokail, Majed S.
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
King Saud Univ, Dept Biochem, Coll Sci, Prince Mutaib Chair Biomarkers Osteoporosis, Riyadh 11451, Saudi ArabiaKing Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia
机构:
St George Hosp, Dept Renal Med, Sydney, NSW, Australia
George Inst Global Hlth, Renal & Metab Div, Level 5,1 King St, Newtown, NSW 2042, Australia
Univ Queensland, Australasian Kidney Trials Network, Brisbane, Qld, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Badve, Sunil V.
;
论文数: 引用数:
h-index:
机构:
Pascoe, Elaine M.
;
Biostat, M.
论文数: 0引用数: 0
h-index: 0
机构:St George Hosp, Dept Renal Med, Sydney, NSW, Australia
Biostat, M.
;
Tiku, Anushree
论文数: 0引用数: 0
h-index: 0
机构:
St George Hosp, Dept Renal Med, Sydney, NSW, Australia
George Inst Global Hlth, Renal & Metab Div, Level 5,1 King St, Newtown, NSW 2042, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Tiku, Anushree
;
论文数: 引用数:
h-index:
机构:
Boudville, Neil
;
Brown, Fiona G.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Monash Med Ctr, Dept Nephrol, Melbourne, Vic, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Brown, Fiona G.
;
Cass, Alan
论文数: 0引用数: 0
h-index: 0
机构:
Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Cass, Alan
;
Clarke, Philip
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, Nuffield Dept Populat Hlth, Hlth Econ Res Ctr, Oxford, EnglandSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Clarke, Philip
;
Dalbeth, Nicola
论文数: 0引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Med, Auckland, New ZealandSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Dalbeth, Nicola
;
Day, Richard O.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Clin Sch, Sydney, NSW, Australia
Univ New South Wales Med, Dept Clin Pharmacol, Sydney, NSW, Australia
Univ New South Wales Med, Dept Toxicol, Sydney, NSW, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Day, Richard O.
;
de Zoysa, Janak R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Med, Auckland, New Zealand
Waitemata Dist Hlth Board, Renal Serv, Auckland, New ZealandSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
de Zoysa, Janak R.
;
Douglas, Bettina
论文数: 0引用数: 0
h-index: 0
机构:
Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Douglas, Bettina
;
Faull, Randall
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Adelaide, SA, Australia
Cent Northern Adelaide Renal & Transplantat Serv, Adelaide, SA, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Faull, Randall
;
Harris, David C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, St Vincents Hosp, Ctr Transplant & Renal Res, Westmead Inst Med Res, Sydney, NSW, Australia
Westmead Hosp, Western Sydney Local Hlth Dist, Dept Renal Med, Sydney, NSW, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Harris, David C.
;
Hawley, Carmel M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Australasian Kidney Trials Network, Brisbane, Qld, Australia
Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Hawley, Carmel M.
;
Jones, Graham R. D.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Clin Sch, Sydney, NSW, Australia
SydPath, Chem Pathol, Sydney, NSW, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Jones, Graham R. D.
;
Kanellis, John
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Monash Med Ctr, Dept Nephrol, Melbourne, Vic, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Kanellis, John
;
Palmer, Suetonia C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Otago Christchurch, Dept Med, Christchurch, New ZealandSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Palmer, Suetonia C.
;
Perkovic, Vlado
论文数: 0引用数: 0
h-index: 0
机构:
George Inst Global Hlth, Renal & Metab Div, Level 5,1 King St, Newtown, NSW 2042, Australia
Royal North Shore Hosp, Dept Nephrol, Sydney, NSW, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Perkovic, Vlado
;
Rangan, Gopala K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, St Vincents Hosp, Ctr Transplant & Renal Res, Westmead Inst Med Res, Sydney, NSW, Australia
Westmead Hosp, Western Sydney Local Hlth Dist, Dept Renal Med, Sydney, NSW, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Rangan, Gopala K.
;
论文数: 引用数:
h-index:
机构:
Reidlinger, Donna
;
Robison, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Australasian Kidney Trials Network, Brisbane, Qld, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Robison, Laura
;
Walker, Robert J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Otago, Dunedin Sch Med, Dunedin, New ZealandSt George Hosp, Dept Renal Med, Sydney, NSW, Australia
Walker, Robert J.
;
论文数: 引用数:
h-index:
机构:
Walters, Giles
;
Johnson, David W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Australasian Kidney Trials Network, Brisbane, Qld, Australia
Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, Australia
Translat Res Inst, Brisbane, Qld, AustraliaSt George Hosp, Dept Renal Med, Sydney, NSW, Australia