Sex-Specific Association of Uric Acid and Kidney Function Decline in Taiwan

被引:13
作者
Chang, Po-Ya [1 ]
Chang, Yu-Wei [2 ]
Lin, Yuh-Feng [3 ]
Fan, Hueng-Chuen [4 ]
机构
[1] Natl Taipei Univ Nursing & Hlth Sci, Dept Leisure Ind & Hlth Promot, Taipei 112, Taiwan
[2] Natl Taichung Univ Sci & Technol, Dept Business Management, Taichung 404, Taiwan
[3] Taipei Med Univ, Grad Inst Clin Med, Taipei 110, Taiwan
[4] Tungs Taichung Metroharbor Hosp, Dept Pediat, Taichung 435, Taiwan
关键词
hyperuricemia; sex; renal progression; chronic kidney disease; POSTMENOPAUSAL HORMONE USE; URATE-LOWERING THERAPY; RISK-FACTOR; CARDIOVASCULAR MORTALITY; METABOLIC SYNDROME; RENAL-DISEASE; SERUM; HYPERURICEMIA; HYPERTENSION; GOUT;
D O I
10.3390/jpm11050415
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
An elevated serum urate concentration is associated with kidney damage. Men's uric acid levels are usually higher than women's. However, postmenopausal women have a higher risk of gout than men, and comorbidities are also higher than in men. This study examined the sex differences in the relationship between hyperuricemia and renal progression in early chronic kidney disease (CKD) and non-CKD, and further examined the incidence of CKD in non-CKD populations among patients over 50 years of age. We analyzed 1856 women and 1852 men participating in the epidemiology and risk factors surveillance of the CKD database. Women showed a significantly higher risk of renal progression and CKD than men within the hyperuricemia group. After adjusting covariates, women, but not men resulted in an hazard ratio (HR) for developing renal progression (HR = 1.12; 95% CI 1.01-1.24 in women and HR = 1.03; 95% CI 0.93-1.13 in men) and CKD (HR = 1.11; 95% CI 1.01-1.22 in women and HR = 0.95; 95% CI 0.85-1.05 in men) for each 1 mg/dL increase in serum urate levels. The association between serum urate levels and renal progression was stronger in women. Given the prevalence and impact of kidney disease, factors that impede optimal renal function management in women and men must be identified to provide tailored treatment recommendations.
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页数:13
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