Copper-Catalyzed Synthesis of Substituted 4-Acylpyrazole Derivatives through a Cascade Transformation from N-Propargylic Sulfonylhydrazones and Diaryliodonium Salts

被引：2

作者：

Li, Ren-Hao ^{[1
,2
]}

Fan, Xin-Yang ^{[1
,2
]}

Hu, Zi-Lin ^{[1
,2
]}

Liu, Zhi-Kai ^{[1
,2
]}

Yang, Ying ^{[1
,2
]}

Tang, Hai-Tao ^{[3
]}

Chen, Yi-Hui ^{[1
,2
]}

Chen, Li ^{[1
,2
]}

Zhan, Zhuang-Ping ^{[1
,2
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen, Fujian, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen, Fujian, Peoples R China

[3] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

来源：

SYNLETT | 2018年 / 29卷 / 17期

关键词：

propargylic sulfonylhydrazones; diaryliodonium salts; cascade transformation; acylpyrazoles; PYRAZOLE DERIVATIVES; ARYLATION; KETONES;

D O I：

10.1055/s-0037-1610271

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise strategy for the synthesis of substituted 4-acylpyrazole derivatives from N-propargylic sulfonylhydrazones and diaryliodonium salts has been developed. The pyrazole derivatives are formed through a five-step cascade sequence that includes intramolecular cyclization, hydroxylation, elimination, copper-catalyzed aerobic oxidation, and intramolecular rearrangement.

引用

页码：2283 / 2287

页数：5

共 12 条

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