Effect of oral supplementation of composite leaf extract of medicinal plants on biomarkers of oxidative stress in induced diabetic Wistar rats

被引：1

作者：

Tiwari, Brahm Kumar ^{[1
,4
]}

Abidi, Abu Baker ^{[1
]}

Rizvi, Syed Ibrahim ^{[2
]}

Pandey, Kanti Bhooshan ^{[2
,3
]}

机构：

[1] SHIATS, Dept Biochem & Biochem Engn, Allahabad, Uttar Pradesh, India

[2] Univ Allahabad, Dept Biochem, Allahabad, Uttar Pradesh, India

[3] Cent Salt & Marine Chem Res Inst, CSIR, Bhavnagar 364002, Gujarat, India

[4] ITS Paramed Coll, Ghaziabad 201206, India

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2018年 / 124卷 / 04期

关键词：

Diabetes; oxidative stress; medicinal plants; composite extract; antioxidant; GLUTATHIONE-PEROXIDASE; LIPID-PEROXIDATION; PROTEIN OXIDATION; ERYTHROCYTES; DAMAGE; BRAIN; COMPLICATIONS; RESVERATROL; PATHWAYS; CATALASE;

D O I：

10.1080/13813455.2017.1411369

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Present study was conducted to evaluate the effect of oral supplementation of composite extract of leaves (CLE) of four medicinal plants; Aegle marmelos, Ocimum sanctum, Murraya koenigii and Azadirachta indica on markers of oxidative stress in brain tissues of alloxan-induced diabetic rats in vivo. Enhanced lipid peroxidation, protein oxidation and reduced antioxidative defence systems were measured in brain tissues of diabetic rats. Supplementation of CLE, once in a day for 35days significantly (p<.05) protected the peroxidation of lipid, oxidation of protein and ameliorated the antioxidant defence in brain tissue of diabetic rats. It was observed that the insulin-like effect of CLE was dose dependent; higher effect at higher doses. The results of the study suggest that supplementation CLE may provide an overall homeostasis and significant neuro-protection through rescuing brain cells from oxidative abuse and accelerating brain antioxidative defence during advanced stage of hyperglycaemia.

引用

页码：361 / 366

页数：6

共 45 条

[1] HETEROGENEITY OF ERYTHROCYTE CATALASE .2. ISOLATION AND CHARACTERIZATION OF NORMAL AND VARIANT ERYTHROCYTE CATALASE AND THEIR SUBUNITS
AEBI, H
WYSS, SR
SCHERZ, B
SKVARIL, F
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1974, 48 (01): : 137 - 145
[2] Standards of Medical Care in Diabetes-2014
不详
[J]. DIABETES CARE, 2014, 37 : S14 - S80
[3] Anyaehie Ugochukwu B, 2009, Niger J Physiol Sci, V24, P157
[4] Dehydroepiandrosterone administration prevents the oxidative damage induced by acute hyperglycemia in rats
Aragno, M
Brignardello, E
Tamagno, E
Gatto, V
Danni, O
Boccuzzi, G
[J]. JOURNAL OF ENDOCRINOLOGY, 1997, 155 (02) : 233 - 240
[5] Role of oxidative stress in diabetic complications - A new perspective on an old paradigm
Baynes, JW
Thorpe, SR
[J]. DIABETES, 1999, 48 (01) : 1 - 9
[6] Beutler E., 1984, GLUTATHIONE PEROXIDA
[7] Burade KB, 2011, J CELL TISSUE RES, V11, P2515
[8] REVERSAL OF AGE-RELATED INCREASE IN BRAIN PROTEIN OXIDATION, DECREASE IN ENZYME-ACTIVITY, AND LOSS IN TEMPORAL AND SPATIAL MEMORY BY CHRONIC ADMINISTRATION OF THE SPIN-TRAPPING COMPOUND N-TERT-BUTYL-ALPHA-PHENYLNITRONE
CARNEY, JM
STARKEREED, PE
OLIVER, CN
LANDUM, RW
CHENG, MS
WU, JF
FLOYD, RA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) : 3633 - 3636
[9] Biomarkers of oxidative damage in human disease
Dalle-Donne, I
Rossi, R
Colombo, R
Giustarini, D
Milzani, A
[J]. CLINICAL CHEMISTRY, 2006, 52 (04) : 601 - 623
[10] Protein carbonyl groups as biomarkers of oxidative stress
Dalle-Donne, I
Rossi, R
Giustarini, D
Milzani, A
Colombo, R
[J]. CLINICA CHIMICA ACTA, 2003, 329 (1-2) : 23 - 38

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