Clinical research in older adults with hematologic malignancies: Opportunities for alignment in the Veterans Affairs

被引：0
作者：
Graf, Solomon A. [1 ,2 ,3 ]
Samples, Laura S. [4 ]
Keating, Tamarind M. [1 ]
Garcia, Jose M. [1 ,5 ]
机构：
[1] VAPSHCS, 1660 South Columbian Way,S-111-ONC, Seattle, WA 98108 USA
[2] Univ Washington, Sch Med, Dept Med, Div Med Oncol, Seattle, WA 98195 USA
[3] Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA
[4] Univ Washington, Sch Med, Dept Med, Div Internal Med, Seattle, WA 98195 USA
[5] Univ Washington, Sch Med, Dept Med, VAPSHCS Geriatr Res & Educ Clin Ctr GRECC,Div Ger, Seattle, WA 98195 USA
来源：
SEMINARS IN ONCOLOGY | 2019年 / 46卷 / 4-5期
关键词：
Hematologic malignancies; Veterans Affairs; Geriatric; Clinical research; HEMATOPOIETIC-CELL TRANSPLANTATION; ASSESSMENT PREDICTS SURVIVAL; GERIATRIC ASSESSMENT; CANCER INCIDENCE; RISK-ASSESSMENT; UNITED-STATES; CHEMOTHERAPY; TOXICITIES; OUTCOMES; ALCOHOL;
D O I：
10.1053/j.seminoncol.2019.09.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Management of hematologic malignancies in older patients is complex and, with recent and anticipated trends in demographics, increasingly common. As a large, nationally integrated medical system the Veterans Affairs has the potential to lead in research to benefit these patients. In this review we describe the evolving treatment paradigms of hematologic malignancies and how they are best fit with older patients through comprehensive evaluation of key vulnerabilities. We also discuss optimization of supportive care and navigation services to target identified risks and challenges aimed at ameliorating the patient's burden of cancer and treatment. Lastly, we discuss opportunities in design of prospective clinical trials to better align with real-world cases, thereby expanding enrollment of and applicability to older patients with hematologic malignancies. Published by Elsevier Inc.
引用
收藏
页码：341 / 345
页数：5
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