Diagnosis and treatment of low-renin hypertension

被引：71

作者：

Mulatero, Paolo ^{[1
]}

Verhovez, Andrea ^{[1
]}

Morello, Fulvio ^{[1
]}

Veglio, Franco ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Med & Expt Oncol, Div Internal Med & Hypertens, I-00173 Rome, Italy

来源：

CLINICAL ENDOCRINOLOGY | 2007年 / 67卷 / 03期

关键词：

D O I：

10.1111/j.1365-2265.2007.02898.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma renin levels can be used to classify hypertension. A significant proportion of hypertensive individuals display a low-renin profile and thus low-renin hypertension (LRH) requires appropriate diagnosis and treatment. LRH includes essential, secondary and genetic forms, the most common of which are low-renin essential hypertension and primary aldosteronism. Several studies have investigated the relationship between PRA status and clinical response to different antihypertensive therapies. The present review will discuss the differential diagnosis of LRH subtypes and the most appropriate treatment options based on the pathophysiological background of this condition.

引用

页码：324 / 334

页数：11

共 114 条

[101] Effect of antihypertensive agents on the development of type 2 diabetes mellitus [J].

Stump, Craig S. ;

Hamilton, Marc T. ;

Sowers, James R. .

MAYO CLINIC PROCEEDINGS, 2006, 81 (06) :796-806

[102]

SUTHERLAND DJ, 1966, CAN MED ASSOC J, V95, P1109

[103] Genetic analysis of the cytochrome P-450c17α (CYP17) and aldosterone synthase (CYP11B2) in Japanese patients with 17α-hydroxylase deficiency [J].

Takeda, Y ;

Yoneda, T ;

Demura, M ;

Furukawa, K ;

Koshida, H ;

Miyamori, I ;

Mabuchi, H .

CLINICAL ENDOCRINOLOGY, 2001, 54 (06) :751-758

[104] Genetic polymorphism of CYP11B2 gene and hypertension in Japanese [J].

Tamaki, S ;

Iwai, N ;

Tsujita, Y ;

Kinoshita, M .

HYPERTENSION, 1999, 33 (01) :266-270

[105] Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population [J].

Tobin, MD ;

Raleigh, SM ;

Newhouse, S ;

Braund, P ;

Bodycote, C ;

Ogleby, J ;

Cross, D ;

Gracey, J ;

Hayes, S ;

Smith, T ;

Ridge, C ;

Caulfield, M ;

Sheehan, NA ;

Munroe, PB ;

Burton, PR ;

Samani, NJ .

CIRCULATION, 2005, 112 (22) :3423-3429

[106] Familial hyperaldosteronism type II: Description of a large kindred and exclusion of the aldosterone synthase (CYP11B2) gene [J].

Torpy, DJ ;

Gordon, RD ;

Lin, JP ;

Huggard, PR ;

Taymans, SE ;

Stowasser, M ;

Chrousos, GP ;

Stratakis, CA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (09) :3214-3218

[107] Effects of eplerenone versus losartan in patients with low-renin hypertension [J].

Weinberger, MH ;

White, WB ;

Ruilope, LM ;

MacDonald, TM ;

Davidson, RC ;

Roniker, B ;

Patrick, JL ;

Krause, SL .

AMERICAN HEART JOURNAL, 2005, 150 (03) :426-433

[108] British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary [J].

Williams, B ;

Poulter, NR ;

Brown, MJ ;

Davis, M ;

McInnes, GT ;

Potter, MF ;

Sever, PS ;

Thom, SM .

BMJ-BRITISH MEDICAL JOURNAL, 2004, 328 (7440) :634-640

[109] Role of HSD11B2 polymorphisms in essential hypertension and the diuretic response to thiazides [J].

Williams, TA ;

Mulatero, P ;

Filigheddu, F ;

Troffa, C ;

Milan, A ;

Argiolas, G ;

Parpaglia, PP ;

Veglio, F ;

Glorioso, N .

KIDNEY INTERNATIONAL, 2005, 67 (02) :631-637

[110] A genetic defect resulting in mild low-renin hypertension [J].

Wilson, RC ;

Dave-Sharma, S ;

Wei, JQ ;

Obeyesekere, VR ;

Li, K ;

Ferrari, P ;

Krozowski, ZS ;

Shackleton, CHL ;

Bradlow, L ;

Wiens, T ;

New, MI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :10200-10205

← 3 4 5 6 7 8 9 10 11 12 →