TIM1 haplotype may control the disease progression to AIDS in a HIV-1-infected female cohort in Thailand

被引：21

作者：

Wichukchinda, Nuanjun ^{[2
]}

Nakajima, Toshiaki ^{[3
]}

Saipradit, Nongluk ^{[2
]}

Nakayama, Emi E. ^{[4
]}

Ohtani, Hitoshi ^{[3
]}

Rojanawiwat, Archawin ^{[2
]}

Pathipvanich, Panita ^{[5
]}

Ariyoshi, Koya ^{[6
,7
]}

Sawanpanyalert, Pathom ^{[2
]}

Shioda, Tatsuo ^{[4
]}

Kimura, Akinori ^{[1
,3
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Mol Pathogenesis, Med Res Inst, Bunkyo Ku, Tokyo 1138510, Japan

[2] NIH, Dept Med Sci, Minist Publ Hlth, Nonthaburi, Thailand

[3] Tokyo Med & Dent Univ, Lab Genome Divers, Grad Sch Biomed Sci, Tokyo 1138510, Japan

[4] Osaka Univ, Dept Viral Infect, Microbial Dis Res Inst, Osaka, Japan

[5] Lampang Hosp, Day Care Ctr, Lampang, Thailand

[6] Nagasaki Univ, Global COE Program, Inst Trop Med, Nagasaki 852, Japan

[7] Nagasaki Univ, Dept Clin Med, Inst Trop Med, Nagasaki 852, Japan

来源：

AIDS | 2010年 / 24卷 / 11期

关键词：

disease progression; HIV-1; polymorphism; survival rate; TIM1; IMMUNOGLOBULIN DOMAIN; HIV-1; INFECTION; MUCIN-DOMAIN; POLYMORPHISMS; GENE; ASSOCIATION; MOLECULE; PROMOTER; ASTHMA; CELLS;

D O I：

10.1097/QAD.0b013e32833a8e6d

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: To investigate association of TIM1 sequence variations with HIV/AIDS progression. Introduction: HIV-1 infected individuals have wide variations in disease progression including AIDS. T cell immunoglobulin and mucin 1 (TIM1) is a cell surface protein involved in the regulation of Th1/Th2 immune response. Materials and methods: We sequenced the highly polymorphic exon 4 of TIM1 from 246 individuals of HIV-1 infected Thai female cohort to determine their TIM1 haplo-types. Associations of TIM1 haplotypes with baseline clinical data (sero-status, plasma viral load, CD4 cell count, and symptomatic AIDS) and survival status during 3 years of follow-up were evaluated. Results: Seven TIM1 haplotypes, D3-A, D4, D3-C, D1, W-A, W-C, and D3-C*, were found in the cohort. Patients possessing the D3-A haplotype showed trends towards higher CD4(+) cell count (P=0.06) and lower proportion of AIDS-related symptoms (P=0.022) than the other patients at the baseline. Kaplan-Meier analysis demonstrated that patients carrying the D3-A haplotype had a better survival rates (P=0.019) than the others. D3-A haplotypes was tightly linked to the lower expression levels of TIM1. Conclusion: TIM1 D3-A haplotype is associated with the delay of disease progression to AIDS in the HIV-1 infected Thai females. (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins

引用

页码：1625 / 1631

页数：7

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