Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development

被引：10

作者：

Abolaban, Fouad A. ^{[1
]}

Djouider, Fathi M. ^{[1
]}

机构：

[1] King Abdulaziz Univ, Fac Engn, Nucl Engn Dept, POB 80204, Jeddah 21589, Saudi Arabia

来源：

OPEN LIFE SCIENCES | 2021年 / 16卷 / 01期

关键词：

SARS-CoV-2; virus; virus genome; virus infectivity; gamma irradiation; virus inactivation; vaccine development; RNA VIRUSES; PHOTODYNAMIC INACTIVATION; SPIKE PROTEIN; TARGET THEORY; RABIES VIRUS; IN-VITRO; CORONAVIRUS; RADIATION; EXORIBONUCLEASE; IDENTIFICATION;

D O I：

10.1515/biol-2021-0051

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Radiation inactivation of enveloped viruses occurs as the result of damages at the molecular level of their genome. The rapidly emerging and ongoing coronavirus disease 2019 (COVID-19) pneumonia pandemic prompted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global health crisis and an economic devastation. The readiness of an active and safe vaccine against the COVID-19 has become a race against time in this unqualified global panic caused by this pandemic. In this review, which we hope will be helpful in the current situation of COVID-19, we analyze the potential use of gamma-irradiation to inactivate this virus by damaging at the molecular level its genetic material. This inactivation is a vital step towards the design and development of an urgently needed, effective vaccine against this disease.

引用

页码：558 / 570

页数：13

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