Metallopeptides for Asymmetric Dirhodium Catalysis

被引：115

作者：

Sambasivan, Ramya ^{[1
]}

Ball, Zachary T. ^{[1
]}

机构：

[1] Rice Univ, Dept Chem, Houston, TX 77251 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 27期

关键词：

SI-H BOND; ARTIFICIAL METALLOENZYMES; CARBENE INSERTION; ACIDS; TECHNOLOGY; ALDEHYDES; PEPTIDES; PROTEIN;

D O I：

10.1021/ja103747h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Natural peptide sequences ligate to dirhodium centers through two bridging aspartate side chains, creating a macromolecular ligand framework with helical structure. The generation of a small peptide library allowed optimization of peptide sequence and produced an efficient catalyst for enantioselective carbenoid insertion into Si-H bonds. Analysis of the library indicates that the i-1 and i+3 positions of nonapeptides have the most significant effect on enantioselectivity, though the structural basis for selectivity is different at each of the positions.

引用

收藏

页码：9289 / 9291

页数：3

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