Natural terpenoids with anti-inflammatory activities: Potential leads for anti-inflammatory drug discovery

被引：92

作者：

Ge, Jiamin ^{[1
,2
,3
]}

Liu, Zhen ^{[2
,3
]}

Zhong, Zhichao ^{[1
,2
,3
]}

Wang, Liwei ^{[2
,3
]}

Zhuo, Xiaotao ^{[2
,3
]}

Li, Junjie ^{[2
,3
]}

Jiang, Xiaoying ^{[4
]}

Ye, Xiang-Yang ^{[2
,3
]}

Xie, Tian ^{[2
,3
]}

Bai, Renren ^{[2
,3
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

[2] Hangzhou Normal Univ, Sch Pharm, Hangzhou 311121, Peoples R China

[3] Hangzhou Normal Univ, Collaborat Innovat Ctr Chinese Med Zhejiang Prov, Key Lab Elemene Class Anticanc Chinese Med, Engn Lab Dev & Applicat Tradit Chinese Med, Hangzhou 311121, Peoples R China

[4] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Key Lab Organosilicon Chem & Mat Technol, Hangzhou 311121, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2022年 / 124卷

基金：

中国国家自然科学基金;

关键词：

Natural products; Terpenoids; Anti-inflammatory activities; Targets; Drug discovery; SESQUITERPENE LACTONES; LABDANE DITERPENOIDS; ANDROGRAPHIS-PANICULATA; TIRUCALLANE TRITERPENOIDS; CYTOKINE PRODUCTION; LEONURUS-JAPONICUS; NEUROLAENA-LOBATA; INFLAMMATION; TRIPTOLIDE; ACTIVATION;

D O I：

10.1016/j.bioorg.2022.105817

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural products are mainly secondary metabolites produced by plants, microorganisms, and animals, which are still abundant in modern drug discovery. Terpenoids are the most diverse group of natural products, attracting extensive attention owing to their various biological activities. This manuscript reviewed the chemical structures, anti-inflammatory activities, and mechanisms of action of 281 terpenoid natural products reported from 2010 to the present. Their biological targets and both in vitro and in vivo screening models were also surveyed and statistically summarized. This review will provide potential anti-inflammatory lead compounds and helpful information to researchers engaged in natural products and anti-inflammatory drug discovery.

引用

页数：24

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