Stage IV advanced diffuse large B-cell lymphoma in human immunodeficiency virus infection with achieving cure by using highly active antiretroviral therapy alone: a case report

被引：5

作者：

Lim, Do Hyoung ^{[1
]}

Rhee, Ji-Young ^{[2
]}

Park, Keon Woo ^{[1
]}

机构：

[1] Dankook Univ, Coll Med, Dankook Univ Hosp, Div Hematol Oncol,Dept Med, Cheonan, South Korea

[2] Dankook Univ, Coll Med, Dankook Univ Hosp, Div Infect Dis,Dept Med, Cheonan, South Korea

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2017年 / 28卷 / 09期

关键词：

Diffuse large B-cell lymphoma; spontaneous regression; antiretroviral therapy; HIV infection; NON-HODGKIN-LYMPHOMA; IMMUNE RECONSTITUTION; COMPLETE REGRESSION; HIV; NIVOLUMAB; CHEMOTHERAPY; REMISSION; BLOCKADE; MELANOMA;

D O I：

10.1177/0956462416686512

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

After the introduction of highly active antiretroviral therapy (HAART), there has been a decrease in the incidence of lymphoma among the HIV-infected population and also significantly improved survival rates. We describe a remarkable case of an HIV-infected patient with advanced stage IV diffuse large B-cell lymphoma (DLBCL), completely regressed with the use of HAARTalone. He remained disease-free for 6 years and he achieved cure without chemotherapy. Although several cases of low-grade lymphoma with complete regression were reported, we could not find any case of stage IV high-grade malignant lymphomawith HAARTalone in complete remission for over 5 years from our review of the literature. This unique case shows the importance of HAART in improving survival and achieving cure in HIV-high-grade malignant lymphoma.

引用

页码：932 / 936

页数：5

共 24 条

[1] Long-Term Complete Regression of Nodal Marginal Zone Lymphoma Transformed Into Diffuse Large B-Cell Lymphoma With Highly Active Antiretroviral Therapy Alone in Human Immunodeficiency Virus Infection [J].

Baraboutis, Ioannis G. ;

Marinos, Leonidas ;

Lekakis, Lazaros J. ;

Papastamopoulos, Vasilios ;

Georgiou, Ourania ;

Tsagalou, Eleftheria P. ;

Rondogianni, Phoeve ;

Apostolidis, John ;

Papadaki, Theodora ;

Skoutelis, Athanasios T. .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2009, 338 (06) :517-521

[2] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

[3] Incidence and mortality from non-Hodgkin lymphoma in Europe: The end of an epidemic? [J].

Bosetti, Cristina ;

Levi, Fabio ;

Ferlay, Jacques ;

Lucchini, Franca ;

Negri, Eva ;

La Vecchia, Carlo .

INTERNATIONAL JOURNAL OF CANCER, 2008, 123 (08) :1917-1923

[4] Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification [J].

Cheson, Bruce D. ;

Fisher, Richard I. ;

Barrington, Sally F. ;

Cavalli, Franco ;

Schwartz, Lawrence H. ;

Zucca, Emanuele ;

Lister, T. Andrew .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) :3059-+

[5] Changing incidence of non-Hodgkin lymphomas in the United States [J].

Clarke, CA ;

Glaser, SL .

CANCER, 2002, 94 (07) :2015-2023

[6] A lymphomagenic role for HIV beyond immune suppression? [J].

Dolcetti, Riccardo ;

Gloghini, Annunziata ;

Caruso, Arnaldo ;

Carbone, Antonino .

BLOOD, 2016, 127 (11) :1403-1409

[7] Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck [J].

Ferris, R. L. ;

Blumenschein, G., Jr. ;

Fayette, J. ;

Guigay, J. ;

Colevas, A. D. ;

Licitra, L. ;

Harrington, K. ;

Kasper, S. ;

Vokes, E. E. ;

Even, C. ;

Worden, F. ;

Saba, N. F. ;

Iglesias Docampo, L. C. ;

Haddad, R. ;

Rordorf, T. ;

Kiyota, N. ;

Tahara, M. ;

Monga, M. ;

Lynch, M. ;

Geese, W. J. ;

Kopit, J. ;

Shaw, J. W. ;

Gillison, M. L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (19) :1856-1867

[8] Lymphoma Immune Reconstitution Inflammatory Syndrome in the Center for AIDS Research Network of Integrated Clinical Systems Cohort [J].

Gopal, Satish ;

Patel, Monita R. ;

Achenbach, Chad J. ;

Yanik, Elizabeth L. ;

Cole, Stephen R. ;

Napravnik, Sonia ;

Burkholder, Greer A. ;

Mathews, W. Christopher ;

Rodriguez, Benigno ;

Deeks, Steven G. ;

Mayer, Kenneth H. ;

Moore, Richard D. ;

Kitahata, Mari M. ;

Richards, Kristy L. ;

Eron, Joseph J. .

CLINICAL INFECTIOUS DISEASES, 2014, 59 (02) :279-286

[9] Remission of human immunodeficiency virus-related lymphoma in association with immune reconstitution on anti-retroviral therapy, without chemotherapy [J].

Griffin, Morag ;

Fielding, Jenna ;

Ahmed, Nadia ;

Gandhi, Shreyans ;

Wright, Josh .

LEUKEMIA & LYMPHOMA, 2016, 57 (09) :2224-2227

[10] Improved Survival with Ipilimumab in Patients with Metastatic Melanoma [J].

Hodi, F. Stephen ;

O'Day, Steven J. ;

McDermott, David F. ;

Weber, Robert W. ;

Sosman, Jeffrey A. ;

Haanen, John B. ;

Gonzalez, Rene ;

Robert, Caroline ;

Schadendorf, Dirk ;

Hassel, Jessica C. ;

Akerley, Wallace ;

van den Eertwegh, Alfons J. M. ;

Lutzky, Jose ;

Lorigan, Paul ;

Vaubel, Julia M. ;

Linette, Gerald P. ;

Hogg, David ;

Ottensmeier, Christian H. ;

Lebbe, Celeste ;

Peschel, Christian ;

Quirt, Ian ;

Clark, Joseph I. ;

Wolchok, Jedd D. ;

Weber, Jeffrey S. ;

Tian, Jason ;

Yellin, Michael J. ;

Nichol, Geoffrey M. ;

Hoos, Axel ;

Urba, Walter J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (08) :711-723

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