Synthesis of small molecule CDC25 phosphatases inhibitors

被引：25

作者：

Contour-Galcéra, MO

Lavergne, O

Brezak, MC

Ducommun, B

Prévost, G

机构：

[1] Inst Henri Beaufour, Ipsen Res Labs, F-91966 Les Ulis, France

[2] Univ Toulouse 3, CNRS UMR 5088, LBCMCP, IFR109,Inst Explorat Fonct Genomes, F-31062 Toulouse, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 23期

关键词：

CDC25; inhibitor; dual specificity phosphatases inhibitor; antiproliferative agent;

D O I：

10.1016/j.bmcl.2004.09.041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A targeted library of small molecules has been prepared to optimize the biological activity of BN82002, our initial lead compound, recently described as an original inhibitor of CDC25 phosphatases. Some of these compounds inhibit CDC25 in the micromolar range and therefore reinforce the interest of CDC25 as an anticancer target. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：5809 / 5812

页数：4

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