State of Art of Cancer Pharmacogenomics in Latin American Populations

被引：26

作者：

Lopez-Cortes, Andres ^{[1
]}

Guerrero, Santiago ^{[2
]}

Ana Redal, Maria ^{[3
]}

Tito Alvarado, Angel ^{[4
]}

Abel Quinones, Luis ^{[5
]}

机构：

[1] Univ Tecnol Equinoccial, Fac Ciencias Salud Eugenio Espejo, Ctr Invest Genet & Genom, Quito 170527, Ecuador

[2] Univ Pompeu Fabra, Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Gene Regulat Stem Cells & Canc Programme, Barcelona 08003, Spain

[3] Univ Buenos Aires, Ctr Diagnost Mol, MEDgen, Inst Fisiopatol & Bioquim Clin,Fac Farm & Bioquim, RA-10001499 Buenos Aires, DF, Argentina

[4] Univ San Martin de Porres, Fac Med, Unidad Bioequivalencia & Med Personalizada, Lima 12, Peru

[5] Univ Chile, Fac Med, Dept Basic Clin Oncol, Lab Chem Carcinogenesis & Pharmacogenet, Santiago 70111, Chile

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 06期

关键词：

cancer; single nucleotide polymorphism; precision medicine; Latin America; pharmacogenetics; pharmacogenomics; CODON; 72; POLYMORPHISM; THIOPURINE S-METHYLTRANSFERASE; GSTM1 GENETIC POLYMORPHISMS; ANDROGEN RECEPTOR GENE; CELL LUNG-CANCER; PROSTATE-CANCER; BRCA2; MUTATIONS; COLORECTAL-CANCER; BREAST-CANCER; GASTRIC-CANCER;

D O I：

10.3390/ijms18060639

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.

引用

页数：22

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