A description of the relationship in healthy longevity and aging-related disease: from gene to protein

被引：6

作者：

Ni, Xiaolin ^{[1
,2
,3
]}

Wang, Zhaoping ^{[1
,2
]}

Gao, Danni ^{[4
]}

Yuan, Huiping ^{[1
,2
]}

Sun, Liang ^{[1
,2
]}

Zhu, Xiaoquan ^{[1
,2
]}

Zhou, Qi ^{[1
,2
]}

Yang, Ze ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Key Lab Geriatr, Beijing Inst Geriatr, Beijing Hosp,Natl Ctr Gerontol,Natl Hlth Commiss, Beijing 100730, Peoples R China

[2] Chinese Acad Med Sci, Inst Geriatr Med, Beijing 100730, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Grad Sch, Beijing 100001, Peoples R China

[4] Peking Univ, Beijing Hosp, Sch Clin Med 5, Beijing, Peoples R China

来源：

IMMUNITY & AGEING | 2021年 / 18卷 / 01期

关键词：

Longevity; Genetic characteristics; Homeostasis; Cardiovascular disease; Alzheimer's disease; ALZHEIMERS-DISEASE; MODEL ORGANISMS; EXPRESSION; MECHANISMS; FOXO3; LESSONS; RISK; APOE; DIET;

D O I：

10.1186/s12979-021-00241-0

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Human longevity is a complex phenotype influenced by both genetic and environmental factors. It is also known to be associated with various types of age-related diseases, such as Alzheimer's disease (AD) and cardiovascular disease (CVD). The central dogma of molecular biology demonstrates the conversion of DNA to RNA to the encoded protein. These proteins interact to form complex cell signaling pathways, which perform various biological functions. With prolonged exposure to the environment, the in vivo homeostasis adapts to the changes, and finally, humans adopt the phenotype of longevity or aging-related diseases. In this review, we focus on two different states: longevity and aging-related diseases, including CVD and AD, to discuss the relationship between genetic characteristics, including gene variation, the level of gene expression, regulation of gene expression, the level of protein expression, both genetic and environmental influences and homeostasis based on these phenotypes shown in organisms.

引用

页数：8

共 70 条

[1] 2020 Alzheimer's disease facts and figures [J].