Combined doxorubicin and cyclophosphamide chemotherapy for nonresectable feline fibrosarcoma

被引：51

作者：

Barber, LG ^{[1
]}

Sorenmo, KU ^{[1
]}

Cronin, KL ^{[1
]}

Shofer, FS ^{[1
]}

机构：

[1] Univ Penn, Sch Vet Med, Dept Clin Studies, Philadelphia, PA 19104 USA

来源：

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION | 2000年 / 36卷 / 05期

关键词：

D O I：

10.5326/15473317-36-5-416

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A retrospective evaluation was performed on 12 cats with nonresectable, histopathologically confirmed fibrosarcomas that were treated with doxorubicin and cyclophosphamide chemotherapy. All of the tumors were located in sites potentially used for vaccination. Six cats had a greater than 50% decrease in gross tumor burden. However, the responses were not durable, with a median response duration of 125 days, All cats developed progressive disease. When animals that received other treatments after doxorubicin-based chemotherapy were eliminated from the analysis, median survival time was significantly longer for cats that responded to chemotherapy compared with the median survival time for nonresponders (242 and 83 days, respectively). These findings may serve as a basis for further evaluating the role of chemotherapy in the treatment of vaccine-associated sarcomas.

引用

页码：416 / 421

页数：6

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