Cytokines and psychopathology:: Lessons from interferon-α

被引：412

作者：

Capuron, L ^{[1
]}

Miller, AH ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA

来源：

BIOLOGICAL PSYCHIATRY | 2004年 / 56卷 / 11期

关键词：

immune system; cytokines; interferon-alpha; mood disorders; depression; pathophysiology;

D O I：

10.1016/j.biopsych.2004.02.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inteiferon-alpha is a potent inducer of the cytokine network and is notorious jbr causing behavioral alterations. Studies on inteiferon-alpha-treated patients reveal at least two distinct syndromes: 1) a mood/cognitive syndrome that appears late during interferon-alpha therapy is responsive to antidepressants and is associated with activation of neuroendocrine pathways and altered serotonin metabolism,: and 2) a neurovegetative syndrome characterized by pychomotor slowing, and fatigue that appears early during inteiferon-alpha treatment is antidepressant nonresponsive and may be mediated by alterations in basal ganglia dopamine metabolism. Findings from inteferon-alpha may provide important clues regarding, the pathophysiology and treatment of cytokine-induced behavioral changes in medically ill patients, while also potentially modeling the development of neuropsychiatric symptoms in patients without medical disordcrs.

引用

页码：819 / 824

页数：6

共 36 条

[1] HIV dementia: the role of the basal ganglia and dopaminergic systems [J].