Hepatitis B viral infection of hepatic progenitor cells. Resolving unresolved questions?

被引：1

作者：

Minuk, G. Y. ^{[1
]}

Baruch, Y. ^{[2
]}

机构：

[1] Univ Manitoba, Dept Med, Sect Hepatol, Winnipeg, MB, Canada

[2] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Liver Unit, POB 9649, IL-31096 Haifa, Israel

来源：

MEDICAL HYPOTHESES | 2016年 / 91卷

关键词：

Hepatitis B virus; Progenitor cells; Stem cells; Neonatal hepatitis; Hepatitis B treatment; Hepatocellular carcinoma and viral hepatitis; MESENCHYMAL STEM-CELLS; HBV INFECTION; IN-VITRO; VIRUS-INFECTION; LIVER; DNA; HEPATOCARCINOGENESIS; DIFFERENTIATION; CHILDREN; IMMUNITY;

D O I：

10.1016/j.mehy.2016.04.011

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Accumulated data to date do not entirely explain the; propensity of the hepatitis B virus (HBV) to cause chronic infections in newborns; failure of antiviral agents to resolve infections or precise mechanism whereby HBV causes hepatocellular carcinoma (HCC). Based on the increased numbers of hepatic stem/progenitor cells (HPCs) present within the neonatal liver, the refractoriness of these cells to the effects of interferons and xenobiotics and their ability to undergo malignant transformation, we hypothesize that HBV infection of HPCs could explain these and perhaps other clinical features of chronic HBV. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：24 / 27

页数：4

共 44 条

[1] Neonatal adaptive immunity comes of age [J].

Adkins, B ;

Leclerc, C ;

Marshall-Clarke, S .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :553-564

[2] Liver stem cells - Implications for hepatocarcinogenesis [J].

Alison, Malcolm R. .

STEM CELL REVIEWS, 2005, 1 (03) :253-260

[3] Hepatitis B Infection Is Associated with Asymptomatic Malaria in the Brazilian Amazon [J].

Andrade, Bruno B. ;

Santos, Cristiane J. N. ;

Camargo, Luis M. ;

Souza-Neto, Sebastiao M. ;

Reis-Filho, Antonio ;

Clarencio, Jorge ;

Mendonca, Vitor R. R. ;

Luz, Nivea F. ;

Camargo, Erney P. ;

Barral, Aldina ;

Silva, Antonio A. M. ;

Barral-Netto, Manoel .

PLOS ONE, 2011, 6 (05)

[4] Mesenchymal stem cells: immune evasive, not immune privileged [J].

Ankrum, James A. ;

Ong, Joon Faii ;

Karp, Jeffrey M. .

NATURE BIOTECHNOLOGY, 2014, 32 (03) :252-260

[5] Does the Hepatitis B Antigen HBx Promote the Appearance of Liver Cancer Stem Cells? [J].

Arzumanyan, Alla ;

Friedman, Tiffany ;

Ng, Irene O. L. ;

Clayton, Marcia M. ;

Lian, Zhaorui ;

Feitelson, Mark A. .

CANCER RESEARCH, 2011, 71 (10) :3701-3708

[6]

BEASLEY RP, 1983, LANCET, V2, P1099

[7]

BRILL S, 1993, P SOC EXP BIOL MED, V204, P261

[8] HBV-induced carcinogenesis [J].

Cougot, Delphine ;

Neuveut, Christine ;

Buendia, Marie Annick .

JOURNAL OF CLINICAL VIROLOGY, 2005, 34 :S75-S78

[9] Immunological basis of stem cell therapy in liver diseases [J].

Cui, Lina ;

Shi, Yongquan ;

Han, Ying ;

Fan, Daiming .

EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2014, 10 (09) :1185-1196

[10] Hepatic progenitor cells in children with chronic hepatitis C: correlation with histopathology, viremia, and treatment response [J].

El-Araby, Hanaa A. ;

Ehsan, Nermine A. ;

Konsowa, Hatem A. ;

Abd-Elaati, Basma M. ;

Sira, Ahmad M. .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2015, 27 (05) :561-569

← 1 2 3 4 5 →