Design and Optimization of a Self-Assembling Complex Based on Microencapsulated Calcium Alginate and Glutathione (CAG) Using Response Surface Methodology

被引：18

作者：

Castro, Ricardo I. ^{[1
]}

Morales-Quintana, Luis ^{[2
]}

Alvarado, Nancy ^{[3
]}

Guzman, Luis ^{[4
]}

Forero-Doria, Oscar ^{[5
]}

Valenzuela-Riffo, Felipe ^{[6
,7
]}

Laurie, V. Felipe ^{[8
]}

机构：

[1] Univ Autonoma Chile, Multidisciplinary Agroind Res Lab, Carrera Ingn Construcc, Inst Ciencias Quim Aplicadas, 5 Poniente 1670, Talca 3460000, Chile

[2] Univ Autonoma Chile, Multidisciplinary Agroind Res Lab, Inst Ciencias Biomed, 5 Poniente 1670, Talca 3460000, Chile

[3] Univ Autonoma Chile, Inst Ciencias Quim Aplicadas, Fac Ingn, Ave El Llano Subercaseaux 2801, Santiago 8910060, Chile

[4] Univ Talca, Dept Clin Biochem & Immunohematol, Fac Hlth Sci, 2 Norte 685, Talca 3460000, Chile

[5] Univ Santo Tomas, Dept Ciencias Basicas, Fac Ciencias, Talca 3460000, Chile

[6] Univ Talca, Programa Doctorado Ciencias Menc Ingn Genet Veget, Inst Ciencias Biol, 2 Norte 685, Talca 3460000, Chile

[7] Univ Talca, Inst Biol Sci, Campus Talca,2 Norte 285, Talca 3460000, Chile

[8] Univ Talca, Fac Ciencias Agr, 2 Norte 285, Talca 3460000, Chile

来源：

POLYMERS | 2021年 / 13卷 / 13期

关键词：

alginate; glutathione; microencapsulated; ENCAPSULATION; BIOPOLYMER; PARTICLES; DELIVERY; BEHAVIOR; BEADS;

D O I：

10.3390/polym13132080

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The aim of this work was to characterize and optimize the formation of molecular complexes produced by the association of calcium alginate and reduced glutathione (GSH). The influence of varying concentrations of calcium and GSH on the production of microcapsules was analyzed using response surface methodology (RSM). The microcapsules were characterized by thermogravimetric analysis (TGA-DTG) and infrared spectroscopy (FTIR) in order to assess the hydration of the complexes, their thermal stability, and the presence of GSH within the complexes. The optimum conditions proposed by RSM to reach the maximum concentration of GSH within complexes were a 15% w/v of GSH and 1.25% w/v of CaCl2, with which a theorical concentration of 0.043 mg GSH per mg of CAG complex was reached.

引用

页数：12

共 55 条

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