Transition metal-free Minisci reaction promoted by NCS, and TBHP: acylation of heteroarenes

被引：45
作者：
Siddaraju, Yogesh [1 ]
Prabhu, Kandikere Ramaiah [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
来源：
TETRAHEDRON | 2016年 / 72卷 / 07期
关键词：
Isoquinoline; Minisci reaction; C-H functionalization; Acylation; Metal-free reactions; DEHYDROGENATIVE COUPLING REACTION; C-H FUNCTIONALIZATION; RADICAL SUBSTITUTION; HOMOLYTIC ACYLATION; BOND ACTIVATION; DIRECT ACCESS; ALDEHYDES; AMIDATION; IODINE; ACETANILIDES;
D O I：
10.1016/j.tet.2015.12.065
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for acylation for heteroarenes under metal-free conditions has been described using NCS as an additive and TBHP as an oxidant. This method has been successfully employed in acylation of a variety of aldehyde with heteroarenes. The application of the method has been illustrated in synthesizing isoquinoline derived natural products. This strategy provides an efficient, mild and inexpensive method for acylation of heteroarenes. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：959 / 967
页数：9
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